Mayo Clinic Laboratory and Pathology Research Roundup: Feb. 12

By Kelley Luedke • February 12, 2018

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Predicting Oncologic Outcomes in Renal Cell Carcinoma After Surgery

Predicting oncologic outcomes is important for patient counseling, clinical trial design, and biomarker study testing. Mayo Clinic researchers conducted a study to develop prognostic models for progression-free and cancer-specific survival in patients with clear cell renal cell carcinoma (ccRCC), papillary RCC (papRCC), and chromophobe RCC (chrRCC). Using a large institutional experience, researchers generated specific prognostic models for oncologic outcomes in ccRCC, papRCC, and chrRCC that rely on features previously shown-and validated-to be associated with survival. These updated models should inform patient prognosis, biomarker design, and clinical trial enrollment. The study was published in European Urology.

Published to PubMed This Week

• • Reduced Active Transcellular Intestinal Oxalate Secretion Contributes to the Pathogenesis of Obesity-Associated Hyperoxaluria
    Kidney International
  • Association of Vitamin D Levels and Risk of Ovarian Cancer: A Mendelian Randomization Study
    International Journal of Epidemiology
  • Mucinous Neoplasm of the Appendix and Pseudomyxoma Peritonei
    Mayo Clinic Proceedings
  • Mutations and Prognosis in Myelodysplastic Syndromes: Karyotype-Adjusted Analysis of Targeted Sequencing in 300 Consecutive Cases and Development of a Genetic Risk Model
    American Journal of Hematology
  • Allogeneic Hematopoietic Stem Cell Transplant Overcomes the Adverse Survival Effect of Very High Risk and Unfavorable Karyotype in Myelofibrosis
    American Journal of Hematology
  • Contraction of T Cell Richness in Lung Cancer Brain Metastases
    Scientific Reports
  • Quinacrine Upregulates p21/p27 Independent of p53 Through Autophagy-Mediated Downregulation of p62-Skp2 Axis in Ovarian Cancer
    Scientific Reports
  • Long-term Mortality After Revision THA
    Clinical Orthopaedics and Related Research
  • Diagnostic Testing for Zika Virus: A Post-Outbreak Update
    Journal of Clinical Microbiology
  • Clinical Presentation of Autoimmune and Viral Encephalitides
    Current Opinion in Critical Care
  • Utility of the Abbott RealTime HCV Genotype Plus RUO Assay Used in Combination with the Abbott RealTime HCV Genotype II Assay
    Journal of Clinical Virology
  • Proportion of Femoral Hernia Repairs Performed for Recurrence in the United States
    Hernia
  • SVAtools for Junction Detection of Genome-Wide Chromosomal Rearrangements by Mate-Pair Sequencing (MPseq)
    Cancer Genetics
  • Combined Intraocular and Systemic Rituximab for Ocular Lymphoproliferative Disorder with Extranodal Marginal Zone Lymphoma-Type Morphology After Heart Transplant
    Journal of AAPOS
  • Implementation of a New Guideline and Educational Sessions to Reduce Low-Value Continuous Pulse Oximetry Among Hospitalized Patients
    Southern Medical Journal
  • Granulomatous Diseases of the Breast and Axilla: Radiological Findings with Pathological Correlation
    Insights Imaging
  • Outcomes of a Large Cohort of Individuals with Clinically Ascertained High-Count Monoclonal B-Cell Lymphocytosis
    Haematologica

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.