Mayo Clinic Laboratory and Pathology Research Roundup: April 9

The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Genetic Evidence for Early Peritoneal Spreading in Pelvic High-Grade Serous Cancer

Most pelvic high-grade serous (HGS) carcinomas have been proposed to arise from tubal primaries that progress rapidly to advanced disease. However, the temporal sequence of ovarian and peritoneal metastases is not well characterized. Mayo Clinic researchers conducted a study to establish the sequence of metastases, phylogenetic relationships among the ovarian and peritoneal carcinomas were determined from single-nucleotide variations (SNVs) in nine tumor regions from each patient with pelvic HGS carcinomas. Somatic SNVs from each tumor sample were used to reconstruct phylogenies of samples from each patient. Variant allele frequencies were used to reconstruct subclone phylogenies in each tumor sample. The genetic evidence that peritoneal implants arose before or concurrently with ovarian implants is consistent with the emerging concept of the extra-ovarian origin of pelvic HGS cancer. The results challenge the concept of stepwise spatial progression from the fallopian primary to ovarian carcinomas to peritoneal dissemination and suggest an alternative progression model where peritoneal spreading of early clones occurs before or in parallel with ovarian metastases. The study was published in Frontiers in Oncology.

Published to PubMed This Week

• • • • • Recurrent STAT3-JAK2 Fusions in Indolent T-cell Lymphoproliferative Disorder of the Gastrointestinal Tract
          Blood
        • Biallelic Alterations in AEBP1 Lead to Defective Collagen Assembly and Connective Tissue Structure Resulting in a Variant of Ehlers-Danlos Syndrome
          American Journal of Human Genetics
        • Recurrent IgG4-related Tubulointerstitial Nephritis Concurrent with Chronic Active Antibody Mediated Rejection: A Case Report
          American Journal of Transplantation
        • Lyme Endocarditis
          American Journal of Medicine
        • Model Combining Pre-Transplant Tumor Biomarkers and Tumor Size Shows More Utility in Predicting Hepatocellular Carcinoma Recurrence and Survival Than the BALAD Models
          World Journal of Gastroenterology
        • Bendamustine and Rituximab (BR) Versus Dexamethasone, Rituximab, and Cyclophosphamide (DRC) in Patients with Waldenström Macroglobulinemia
          Annals of Hematology
        • Are High-Sensitivity Cardiac Troponin I Values Stable Between Preoperative Visit and Day of Non-Cardiac Surgery?
          Clinical Biochemistry
        • Description of Analytical Method and Clinical Utility of Measuring Serum 7-Alpha-Hydroxy-4-Cholesten-3-One (7aC4) by Mass Spectrometry
          Clinical Biochemistry
        • Microinfarcts and Blood Pressure Trajectories: Response to Dr Niu et al.
          Journal of Human Hypertension
        • Serum Cortisol Levels via Radioimmunoassay vs Liquid Chromatography Mass Spectrophotometry in Healthy Control Subjects and Patients With Adrenal Incidentalomas
          Laboratory Medicine