Mayo Clinic Laboratory and Pathology Research Roundup: July 30

By Kelley Luedke • July 30, 2018

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Randomized Trial of Spheroid Reservoir Bioartificial Liver in Porcine Model of Post-Hepatectomy Liver Failure

Acute Liver Failure (ALF) is a catastrophic condition that can occur after major liver resection. Mayo Clinic researchers conducted a study to determine the effects of the spheroid reservoir bio-artificial liver (SRBAL) on survival, serum chemistry and liver regeneration in post-hepatectomy ALF pigs. Wild-type large white swine (20-30kg) underwent ICP probe placement followed by 85% hepatectomy. CT volumetrics were performed to measure the extent of resection, and at 48 hours post-hepatectomy to assess regeneration of the remnant liver. Animals were randomized into three groups based on treatment delivered 24 to 48 hour post-hepatectomy. The SRBAL improved survival, reduced ammonia, and accelerated liver regeneration in post-hepatectomy ALF. Improved survival was associated with a neuroprotective benefit of SRBAL therapy. These favorable results warrant further clinical testing of the SRBAL. The study was published in the Hepatology.

Published to PubMed This Week

• • • • • BK Nephropathy with Glomerular Involvement
          Kidney International
        • Glial Fibrillary Acidic Protein IgG Related Myelitis: Characterization and Comparison with Aquaporin-4-IgG Myelitis
          Journal of Neurology, Neurosurgery, and Psychiatry
        • Karyomegalic Interstitial Nephritis in a Renal Allograft
          American Journal of Transplantation
        • p53 Upregulated by HIF-1α Promotes Hypoxia-induced G2/M Arrest and Renal Fibrosis in vitro and in vivo
          Journal of Molecular Cell Biology
        • CDKN2A Germline Rare Coding Variants and Risk of Pancreatic Cancer in Minority Populations
          Cancer Epidemiology, Biomarkers & Prevention
        • Development of Vitamin D Toxicity from Overcorrection of Vitamin D Deficiency: A Review of Case Reports
          Nutrients
        • Morphometric Study of Pulmonary Arterial Changes in Pulmonary Langerhans Cell Histiocytosis
          Archives of Pathology & Laboratory Medicine
        • Exciting Advances in the Pathogenesis of Neoplastic and Nonneoplastic Lung Diseases, Their Diagnosis, Prognosis, and Treatment
          Archives of Pathology & Laboratory Medicine
        • Postoperative Bleeding Risk Prediction for Patients Undergoing Colorectal Surgery
          Surgery
        • Prevalence of Biotin Supplement Usage in Outpatients and Plasma Biotin Concentrations in Patients Presenting to the Emergency Department
          Clinical Biochemistry
        • A Test Utilization Approach to the Diagnostic Workup of Isolated Eosinophilia in Otherwise Morphologically Unremarkable Bone Marrow: A Single Institutional Experience
          American Journal of Clinical Pathology
        • A Systematic Overview of Zoonotic Helminth Infections in North America
          Laboratory Medicine

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.