The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.
Acute Liver Failure (ALF) is a catastrophic condition that can occur after major liver resection. Mayo Clinic researchers conducted a study to determine the effects of the spheroid reservoir bio-artificial liver (SRBAL) on survival, serum chemistry and liver regeneration in post-hepatectomy ALF pigs. Wild-type large white swine (20-30kg) underwent ICP probe placement followed by 85% hepatectomy. CT volumetrics were performed to measure the extent of resection, and at 48 hours post-hepatectomy to assess regeneration of the remnant liver. Animals were randomized into three groups based on treatment delivered 24 to 48 hour post-hepatectomy. The SRBAL improved survival, reduced ammonia, and accelerated liver regeneration in post-hepatectomy ALF. Improved survival was associated with a neuroprotective benefit of SRBAL therapy. These favorable results warrant further clinical testing of the SRBAL. The study was published in the Hepatology.