What’s Next in Precision Medicine: Moving New Discoveries into Daily Clinical Care

Experts in individualized medicine—the concept of shaping health care based on lifestyle, environment, and genetic code—will be in Rochester September 12–13 to present how the newest discoveries can be applied to personalized health care. These experts will be available for interviews at Individualizing Medicine 2018: Advancing Care through Genomics, which will be held at the Mayo Civic Center. The Individualizing Medicine Conference is sponsored by the Mayo Clinic Center for Individualized Medicine.

How the New Genomic Era of Medicine Is Advancing Options for Individualized Care
In the 15 years since the first human genome was mapped, the cost of sequencing your entire DNA has plummeted to just a few hundred dollars. Instead of taking years, DNA sequencing can be performed in weeks or days. DNA testing now plays an important role in the diagnosis and treatment of a wide range of health care conditionseven those who are healthy. Experts who can discuss how genomic medicine may influence future health care are Eric Green, M.D., Ph.D., Director, National Human Genome Research Institute, and Keith Stewart, M.B., Ch.B., Carlson and Nelson Endowed Director, Mayo Clinic Center for Individualized Medicine.

Your Best Defense against Cancer May Be Found within Your Individual Genetic Blueprint
Research on a molecular level is unlocking new understanding of the power of the human body in the fight against cancer. Treatments, like chimeric antigen receptor (CAR) T-cell therapy, seek to unleash the immune system to search and destroy cancer. Advanced DNA testing panels may reveal whether a tumor is linked to a genetic mutation a person was born with. The results may affect treatment and take the guesswork out of who else in your family is at increased risk for cancer. Experts available for interview are Yi Lin, M.D., Ph.D., oncologist, Mayo Clinic Cancer Center (CAR T-cell Therapy); Michael Berger, Ph.D., geneticist, Memorial Sloan Kettering Cancer Center (advanced genomic testing); Kevin Halling, M.D., Ph.D., consultant, Mayo Clinic Department of Laboratory Medicine and Pathology (hereditary cancer); and Heidi Nelson, M.D., Director, Mayo Clinic Center for Individualized Medicine Microbiome Program (microbiome role in cancer).

Gene Editing: Ethical and Health Care Considerations 
Could a tool that acts as a "molecular scissor" slice and remove diseased DNA? Or would some try to manipulate human embryos to create super babies with outstanding intelligence, talent, and beauty? Intriguing as gene editing may sound, there are many ethical and health care implications to consider. Megan Allyse, Ph.D., bioethicist in the Mayo Clinic Center for Individualized Medicine, can discuss the advantages and limitations.

Artificial Intelligence–Will a Machine Decide Your Health Care?
Research at Mayo Clinic is probing whether artificial intelligence can reduce the trial and error in prescribing medications such as antidepressants. Also known as augmented human intelligence, artificial intelligence combines deep computer analysis with human know-how to crack complex health conditions. Experts available for interviews are Liewei Wang, M.D., Ph.D., Mayo Clinic Center for Individualized Medicine; Craig Mermel, M.D., Ph.D., Google Artificial Intelligence; Gabriel Krestin, M.D., Ph.D., machine learning and imaging, University Medical Center, Rotterdam, Netherlands; and Manolis Kellis, Ph.D., epigenomic applications of artificial intelligence, Massachusetts Institute of Technology Broad Institute.

Pharmacogenomics: Medications Matched to Your Genetic Blueprint 
One size does not fit all when it comes to medication. Research is uncovering ways health care providers can tap genetic blueprints to make decisions on individualized therapies for conditions ranging from cancer to depression. A standard drug that works for most patients might not work as intended for a patient. Or it could cause painful, life-threatening side effects. Experts who can talk about the importance of preemptive pharmacogenomics testing are Richard Weinshilboum, M.D., Co-Director, Pharmacogenomics Program, Mayo Clinic Center for Individualized Medicine; Imad Absah, M.D., pediatric gastroenterologist at Mayo Clinic; Teresa Kruisselbrink, supervisor and genetic counselor, Mayo Clinic Center for Individualized Medicine; and Timothy Curry, M.D., Ph.D.,Education Program, Mayo Clinic Center for Individualized Medicine Education.

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This post was written and originally published by the Mayo Clinic News Network. To see the latest news from Mayo Clinic, go to http://newsnetwork.mayoclinic.org. The editor of the News Network site is Dana Sparks.

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