Mayo Clinic Laboratory and Pathology Research Roundup: Sept. 24

By Kelley Luedke • September 24, 2018

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Limitations of Platform Assays to Measure Serum 25OHD Level Impact on Guidelines and Practice Decision-Making

Liquid Chromatography Mass Spectroscopy (LC-MS/MS) is the preferred method to measure 25 hydroxyvitamin D (25OHD) levels, but laboratories are increasingly adopting automated platform assays. Mayo Clinic researchers assessed the performance of commonly used automated immunoassays, with that of LC-MS/MS, and the National Institute of Standards and Technology (NIST) reference values, to measure 25OHD levels. They compared serum 25OHD levels obtained from 219 elderly subjects, enrolled in a vitamin D trial, using the Diasorin Liaison platform assay, and the tandem LC-MS/MS method. Researchers also assessed the performance of the Diasorin and Roche automated assays, expressed as mean percent bias from the NIST standards, based on the vitamin D External Quality Assessment Scheme (DEQAS) reports, from 2013 to 2017. The performance of most widely used automated assays is sub-optimal. Researchers findings underscore the pressing need to re-consider current practices with regards to 25OHD measurements, interpretation of results from research studies, meta-analyses, the development of vitamin D guidelines, and their relevance to optimizing health. The study was published in Metabolism.

Published to PubMed This Week

• • • • • Therapeutic Targeting of PFKFB3 with a Novel Glycolytic Inhibitor PFK158 Promotes Lipophagy and Chemosensitivity in Gynecologic Cancers
          International Journal of Cancer
        • Bone Marrow Biopsy Operator Experience and Impact on Aspirate, Biopsy, and Ancillary Testing Quality
          Mayo Clinic Proceedings: Innovations, Quality & Outcomes
        • Follicular Dendritic Cell Sarcoma With Indolent T-Lymphoblastic Proliferation is Associated With Paraneoplastic Autoimmune Multiorgan Syndrome
          American Journal of Surgical Pathology
        • Associations of catechol-O-methyltransferase (rs4680) Single Nucleotide Polymorphisms with Opioid Use and Dose Among Adults with Chronic Pain
          Pain
        • A Novel Predictive Model of Outcome in Acute Myeloid Leukemia without Favorable Karyotype Based on Treatment Strategy, Karyotype and FLT3-ITD Mutational Status
          American Journal of Hematology
        • Impact of Clone Size With a Single Cytogenetic Abnormality on the Revised International Prognostic Scoring System in Myelodysplastic Syndromes
          American Journal of Hematology
        • The Association of Physical Activity Before and After Lymphoma Diagnosis with Survival Outcomes
          American Journal of Hematology
        • Kidney-Resident Macrophages Promote a Proangiogenic Environment in the Normal and Chronically Ischemic Mouse Kidney
          Scientific Reports
        • Telemedicine in Long-Term Care of Glaucoma Patients
          Journal of Telemedicine and Telecare
        • Clinical and Laboratory Diagnosis of Autoimmune Factor V Inhibitors: A Single Institutional Experience
          Thrombosis Research
        • Embryonic Lethality in Mice Due to Carnitine Transporter OCTN2 Defect and Placental Carnitine Deficiency
          Placenta
        • Macrophage Density Predicts Facial Nerve Outcome and Tumor Growth after Subtotal Resection of Vestibular Schwannoma
          Journal of Neurological Surgery
        • Risk Prediction Models for Cancer-Specific Survival Following Cytoreductive Nephrectomy in the Contemporary Era
          Urologic Oncology

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.