The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.
Featured Abstract
Mayo Clinic researchers conducted a study to describe paraneoplastic neuronal intermediate filament (NIF) autoimmunity. Archived patient and control serum and CSF specimens were evaluated by tissue-based indirect immunofluorescence assay (IFA). Autoantigens were identified by Western blot and mass spectrometry. NIF specificity was confirmed by dual tissue section staining and 5 recombinant NIF-specific HEK293 cell-based assays (CBAs, for α-internexin, neurofilament light [NfL], neurofilament medium, or neurofilament heavy chain, and peripherin). NIF-immunoglobulin Gs (IgGs) were correlated with neurologic syndromes and cancers. NIF-IgG detection by IFA, with confirmatory CBA testing that yields a profile including NfL-IgG, defines a paraneoplastic CNS disorder (usually ataxia or encephalopathy) accompanying neuroendocrine lineage neoplasia. The study was published in Neurology.
Published to PubMed This Week
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- SD-CNN: A Shallow-Deep CNN for Improved Breast Cancer Diagnosis
Computerized Medical Imaging and Graphics - Solitary Lung Nodule.
Mayo Clinic Proceedings - Histiocyte-rich Rhabdomyoblastic Tumor: Rhabdomyosarcoma, Rhabdomyoma, or Rhabdomyoblastic Tumor of Uncertain Malignant Potential? A Histologically Distinctive Rhabdomyoblastic Tumor in Search of a Place in the Classification of Skeletal Muscle Neoplasms
Modern Pathology - Cationic Carrier Peptide Enhances Cerebrovascular Targeting of Nanoparticles in Alzheimer's Disease Brain
Nanomedicine - Diagnostic Utility of Complement Serology for Atypical Hemolytic Uremic Syndrome
Mayo Clinic Proceedings - Medical Parasitology Taxonomy Update, 2016-2017
Journal of Clinical Microbiology - Cardiac Troponin and Natriuretic Peptide Analytical Interferences from Hemolysis and Biotin: Educational Aids from the IFCC Committee on Cardiac Biomarkers (IFCC C-CB)
Clinical Chemistry and Laboratory Medicine - Sellar Region Atypical Teratoid/Rhabdoid Tumors in Adults: Clinicopathological Characterization of Five Cases and Review of the Literature
Journal of Neuropathology & Experimental Neurology - Open Staged Repair of Splenic and Extensive Superior Mesenteric Artery Aneurysms
Journal of Vascular Surgery - Whole-Genome Sequencing for Methicillin-Resistant Staphylococcus Aureus (MRSA) Outbreak Investigation in a Neonatal Intensive Care Unit
Infection Control & Hospital Epidemiology - Evaluation of the Siemens ADVIA Centaur High-Sensitivity Cardiac Troponin I Assay in Serum
Clinica Chimica Acta - FGFR1 Rearranged Hematological Neoplasms - Molecularly Defined and Clinically Heterogeneous
Leukemia & Lymphoma - Implementation of a Reformulated Roche® Bilirubin Gen.3 Reagent Did Not Affect the Relationship Between BiliChek Transcutaneous and Roche Total Serum Bilirubin
Clinical Biochemistry - Role of Prolonged Blood Culture Incubation in Infective Endocarditis Diagnosis
European Journal of Clinical Microbiology & Infectious Diseases - Activity of Fixed Direct Electrical Current in Experimental Staphylococcus Aureus Foreign-Body Osteomyelitis
Diagnostic Microbiology and Infectious Disease
- SD-CNN: A Shallow-Deep CNN for Improved Breast Cancer Diagnosis
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