The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.
Featured Abstract
A Mechanism for Preventing Asymmetric Histone Segregation onto Replicating DNA Strands
How parental histone (H3-H4)2 tetramers, the primary carriers of epigenetic modifications, are transferred onto leading and lagging strands of DNA replication forks for epigenetic inheritance remains elusive. Mayo Clinic researchers show that parental (H3-H4)2 tetramers are assembled into nucleosomes onto both leading and lagging strands, with a slight preference for lagging strands. The lagging-strand preference increases markedly in budding yeast cells lacking Dpb3 and Dpb4, two subunits of the leading strand DNA polymerase, Pol ε, owing to the impairment of parental (H3-H4)2 transfer to leading strands. Dpb3-Dpb4 binds H3-H4 in vitro and participates in the inheritance of heterochromatin. These results indicate that different proteins facilitate the transfer of parental (H3-H4)2 onto leading versus lagging strands and that Dbp3-Dpb4 plays an important role in this poorly understood process. The study was published in Science.
Published to PubMed This Week
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- Effect of Inorganic Nitrite vs. Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial
JAMA - The Return of Actionable Variants Empirical (RAVE) Study, a Mayo Clinic Genomic Medicine Implementation Study: Design and Initial Results
Mayo Clinic Proceedings - Classic Hodgkin Lymphoma
Mayo Clinic Proceedings
- Novel BRAF Alteration in Desmoplastic Infantile Ganglioglioma with Response to Targeted Therapy
Acta Neuropathologica Communications - A Risk-Stratified Approach to Neoadjuvant Chemotherapy in Muscle-Invasive Bladder Cancer: Implications for Patients Classified with Low-Risk Disease
World Journal of Urology - Adamantinoma of Bone: Long-Term Follow-up of 46 Consecutive Patients
Journal of Surgical Oncology - Diagnostic Laboratory Standardization and Validation of Platelet Transmission Electron Microscopy
Platelets - Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
Journal of Visualized Experiments
- Effect of Inorganic Nitrite vs. Placebo on Exercise Capacity Among Patients With Heart Failure With Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial
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