Mayo Clinic Laboratory and Pathology Research Roundup: Nov. 19

By Kelley Luedke • November 19, 2018

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The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.

Featured Abstract

Association of Apolipoprotein E ε4 with Transactive Response DNA-Binding Protein 43

Transactive response DNA-binding protein 43 (TDP-43) is associated with Alzheimer disease (AD), progressive hippocampal atrophy, and cognitive decline. The apolipoprotein E (APOE) ε4 allele is strongly associated with β-amyloid (Aβ) aggregation and risk of AD, but its association with TDP-43 is unknown. Mayo Clinic researchers conducted a study to determine whether the APOE ε4 allele is a risk factor for TDP-43. Transactive response DNA-binding protein 43 was the main outcome of interest. Researchers hypothesized that the APOE ε4 allele would be significantly directly and indirectly associated with TDP-43. The study's findings, which mapped a system of risk factors and outcomes, showed that the APOE ε4 allele appears to be a risk factor for TDP-43 independently of Aβ in patients with AD. The study was published in JAMA Neurology.

Published to PubMed This Week

• • • • • High-grade Dysplasia in Resected Main-duct Intraductal Papillary Mucinous Neoplasm (MD-IPMN) is Associated with an Increased Risk of Subsequent Pancreatic Cancer
          American Journal of Gastroenterology
        • Prognostic and Therapeutic Significance of Phosphorylated STAT3 and Protein Tyrosine Phosphatase-6 in Peripheral-T Cell Lymphoma
          Blood Cancer Journal
        • Lenalidomide Plus R-CHOP21 in Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL): Long-Term Follow-Up Results from a Combined Analysis from Two Phase 2 Trials
          Blood Cancer Journal
          
        • A 40-Year-Old Man With Albinism and Progressive Dyspnea
          Chest
        • Long-Term Outcomes of Eculizumab-Treated Positive Crossmatch Recipients: Allograft Survival, Histologic Findings, and Natural History of the Donor-Specific Antibodies
          American Journal of Transplantation
        • Nasal Vestibulitis: An Under-Recognized and Under-Treated Side Effect of Cancer Treatment?
          Support Care Cancer
        • Novel Germline Missense DDX41 Variant in a Patient with an Adult-Onset Myeloid Neoplasm with Excess Blasts without Dysplasia
          Leukemia & Lymphoma
          
        • Corticotropin Hormone Assay Interference: A Case Series
          Clinical Biochemistry
        • HLA-B*45:22: A Novel Allele that Differs from HLA-B*45:01:01 at Several Locations
          HLA
        • Surgical Trends of Groin Hernia Repairs Performed for Recurrence in Medicare Patients
          Hernia
          
        • Maintaining the Health of the Renal Allograft: Laboratory and Histologic Monitoring After Kidney Transplantation
          Clinics in Laboratory Medicine
        • The Role of Human Leukocyte Antigen in Celiac Disease Diagnostics
          Clinics in Laboratory Medicine
          
        • Mayo Alliance Prognostic System for Mastocytosis: Clinical and Hybrid Clinical-Molecular Models
          Blood Advances

Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Clinic Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.