Mayo Clinic Laboratory and Pathology Research Roundup: Nov. 19

The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.


Featured Abstract

Association of Apolipoprotein E ε4 with Transactive Response DNA-Binding Protein 43

Transactive response DNA-binding protein 43 (TDP-43) is associated with Alzheimer disease (AD), progressive hippocampal atrophy, and cognitive decline. The apolipoprotein E (APOE) ε4 allele is strongly associated with β-amyloid (Aβ) aggregation and risk of AD, but its association with TDP-43 is unknown. Mayo Clinic researchers conducted a study to determine whether the APOE ε4 allele is a risk factor for TDP-43. Transactive response DNA-binding protein 43 was the main outcome of interest. Researchers hypothesized that the APOE ε4 allele would be significantly directly and indirectly associated with TDP-43. The study's findings, which mapped a system of risk factors and outcomes, showed that the APOE ε4 allele appears to be a risk factor for TDP-43 independently of Aβ in patients with AD. The study was published in JAMA Neurology.


Published to PubMed This Week

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Kelley Luedke

Kelley Luedke is a Marketing Channel Manager at Mayo Medical Laboratories. She is the principle editor and writer of Insights and leads social media and direct marketing strategy. Kelley has worked at Mayo Clinic since 2013. Outside of work, you can find Kelley running, traveling, playing with her kitty, and exploring new foods.