The Research Roundup provides an overview of the past week’s research from Mayo Medical Laboratories consultants, including featured abstracts and complete list of published studies and reviews.
Transactive response DNA-binding protein 43 (TDP-43) is associated with Alzheimer disease (AD), progressive hippocampal atrophy, and cognitive decline. The apolipoprotein E (APOE) ε4 allele is strongly associated with β-amyloid (Aβ) aggregation and risk of AD, but its association with TDP-43 is unknown. Mayo Clinic researchers conducted a study to determine whether the APOE ε4 allele is a risk factor for TDP-43. Transactive response DNA-binding protein 43 was the main outcome of interest. Researchers hypothesized that the APOE ε4 allele would be significantly directly and indirectly associated with TDP-43. The study's findings, which mapped a system of risk factors and outcomes, showed that the APOE ε4 allele appears to be a risk factor for TDP-43 independently of Aβ in patients with AD. The study was published in JAMA Neurology.