Mayo Clinic Laboratory and Pathology Research Roundup: Jan. 7
The Research Roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
The Role of 3D-MRE in the Diagnosis of NASH in Obese Patients Undergoing Bariatric Surgery
The lack of reliable, noninvasive methods to diagnose early nonalcoholic steatohepatitis (NASH) is a major unmet need. Mayo Clinic researchers aimed to determine the diagnostic accuracy of 3D-MRE, with shear stiffness measured at 60 Hz, damping ratio at 40 Hz, and MRI proton density fat fraction (MRI-PDFF) in the detection of NASH in individuals undergoing bariatric surgery. Obese adults at risk for NASH were enrolled between 2015–2017 and 2010–2013. The imaging protocol consisted of multifrequency 3D-MRE (mf3D-MRE) with shear waves delivered at different frequencies to explore parameters that best correlated with histologic NASH; and MRI-PDFF to estimate steatosis. The prospective cohort was used to establish the optimal mf3D-MRE technical parameters for NASH detection. The 2 cohorts were then combined to derive predictive models of NASH and disease activity by NAFLD activity score (NAS) using the 3 imaging parameters that correlated with NASH. From the complex shear modulus output generated by mf3D-MRE, the damping ratio at 40 Hz and shear stiffness at 60 Hz best correlated with NASH. The fat fraction obtained from MRI-PDFF correlated with steatosis. Multifrequency 3D-MRE allows identification of novel imaging parameters that predict early NASH and disease activity. This imaging biomarker represents a promising alternative to liver biopsy for NASH diagnosis and monitoring. The study was published in Hepatology.
Published to PubMed This Week
-
-
-
-
- Clinical, Radiologic, and Prognostic Features of Myelitis Associated with Myelin Oligodendrocyte Glycoprotein Autoantibody
JAMA Neurology
- Molecular Signatures of X Chromosome Inactivation and Associations with Clinical Outcomes in Epithelial Ovarian Cancer
Human Molecular Genetics
- Rapid Assessment of Hyperdiploidy in Plasma Cell Disorders Using a Novel Multi-Parametric Flow Cytometry Method
American Journal of Hematology
- IGH Translocations in Chronic Lymphocytic Leukemia (CLL): Clinicopathologic Features and Clinical Outcomes
American Journal of Hematology - High-Sensitivity M-Protein Detection in a Case of Light-Chain Cardiac Amyloidosis Without Evidence of Plasma Cell Dyscrasia
American Journal of Hematology
- Glioblastoma of the Cerebellopontine Angle and Internal Auditory Canal Mimicking a Peripheral Nerve Sheath Tumor: Case Report
Journal of Neurosurgery
- Desmoplastic Small Round Cell Tumors with Atypical Presentations: A Report of 34 Cases
International Journal of Surgical Pathology - Identification and Development of a Lung Adenocarcinoma PDX Model with STRN-ALK Fusion
Clinical Lung Cancer
- Hamartomas and Malformations of the Liver
Seminars in Diagnostic Pathology - Unidentified Anion Gap Metabolic Acidosis
Clinical Biochemistry - Quality of Life at Diagnosis Predicts Overall Survival in Patients with Aggressive Lymphoma
Hematological Oncology
- Clinical, Radiologic, and Prognostic Features of Myelitis Associated with Myelin Oligodendrocyte Glycoprotein Autoantibody
-
-
-