Mayo Clinic Laboratory and Pathology Research Roundup: March 4

By Alyssa Frank • March 4, 2019

Share this:

The Research Roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Recommendations for Institutions Transitioning to High-Sensitivity Troponin Testing: JACC Scientific Expert Panel

High-sensitivity cardiac troponin (hs-cTn) I or T methods have been in use in certain regions for years but are now increasingly globally adopted, including in the United States. Accordingly, inevitable challenges are created for institutions transitioning from conventional cardiac troponin (cTn) assays. hs-cTn assays have higher analytic precision at lower concentrations, yielding greater clinical sensitivity for myocardial injury and allowing accurate recognition of small changes in troponin concentration (rise or fall) within a short time frame. Although much of the knowledge regarding troponin biology that was applicable with older troponin assays still holds true, considerable education regarding the differences between conventional cTn and hs-cTn is needed before medical systems convert to the newer methods. This includes a basic understanding of how hs-cTn testing differs from conventional cTn testing and how it is best deployed in different settings, such as the emergency department and inpatient services.

Published to PubMed This Week

• • • • • The Effect of CRM1 Inhibition on Human Non-Hodgkin Lymphoma Cells
          Blood Cancer Journal
          
        • Treatment Strategies in Diffuse Midline Gliomas with the H3K27M Mutation: The Role of Convection-Enhanced Delivery in Overcoming Anatomic Challenges
          Frontiers in Oncology
          
        • Validation of a Clinicopathological Score for the Prediction of Post-Surgical Evolution of Pituitary Adenoma: Retrospective Analysis on 566 Patients from a Tertiary Care Centre
          European Journal of Endocrinology
        • Combinatorial Tissue Engineering Partially Restores Function after Spinal Cord Injury
          Journal of Tissue Engineering and Regenerative Medicine
        • Multiple Unilateral Subcapsular Cortical Hemorrhagic Cystic Disease of the Kidney: CT and MRI Findings and Clinical Characteristic
          European Radiology
          
        • Hermansky-Pudlak Syndrome and Oculocutaneous Albinism in Chinese Children with Pigmentation Defects and Easy Bruising
          Orphanet Journal of Rare Diseases
        • Clinical Predictors and Survival Outcome of Patients Receiving Suboptimal Neoadjuvant Chemotherapy and Radical Cystectomy for Muscle-Invasive Bladder Cancer: A Single-Center Experience
          World Journal of Urology
        • A Near-Haploid Clone Harboring a BCR/ABL1 Gene Fusion in an Adult Patient with Newly Diagnosed B-Lymphoblastic Leukemia
          Genes, Chromosomes, and Cancer
          
        • Paraneoplastic Autoimmunity and Small-Cell Lung Cancer: Neurological and Serological Accompaniments
          Thoracic Cancer
        • Induced Pluripotent Stem Cell-Derived Cardiomyocytes from a Patient with MYL2-R58Q-Mediated Apical Hypertrophic Cardiomyopathy Show Hypertrophy, Myofibrillar Disarray, and Calcium Perturbations
          Journal of Cardiovascular Translational Research

Alyssa Frank

Alyssa Frank is a Marketing Segment Manager at Mayo Clinic Laboratories. She leads marketing strategies for product management and specialty testing. Alyssa has worked at Mayo Clinic since 2015.