Mayo Clinic Laboratory and Pathology Research Roundup: March 11

By Alyssa Frank • March 11, 2019

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The Research Roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Assay to Rapidly Screen for Immunoglobulin Light Chain Glycosylation: A Potential Path to Earlier AL Diagnosis for a Subset of Patients

Systemic light-chain (LC) amyloidosis (AL) is a protein misfolding disease in which a monoclonal immunoglobulin LC self-aggregates to form insoluble amyloid fibrils, which deposit in different organs and impair the physiology of organs. Researchers postulated that glycosylation also has a pathogenic effect on LCs, and glycosylated LCs could be more prone to being amyloidogenic. Pathogenic glycosylation of proteins has been implicated in various hematological malignancies, often with prognostic implications. However, in comparison with other diseases, glycosylation of LCs has been relatively underinvestigated in AL. This is largely due to the lack of a high-throughput procedure to facilitate rapid analysis of LC glycosylation.

Published to PubMed This Week

• • • • • Beneficial Effects of Sacubitril/Valsartan in Heart Failure with Reduced Ejection Fraction: Pas à Cause du BNP?
          European Journal of Heart Failure
          
        • Posterior Mediastinal Schwannoma (Neurilemmoma)
          Mayo Clinic Proceedings
          
        • 3023 Mayo Clinic Patients with Myeloproliferative Neoplasms: Risk-Stratified Comparison of Survival and Outcomes Data among Disease Subgroups
          Mayo Clinic Proceedings
        • Two Types of Amyloidosis Presenting in a Single Patient: A Case Series
          Blood Cancer Journal
        • World Health Organization Class-Independent Risk Categorization in Mastocytosis
          Blood Cancer Journal
          
        • Clinical Features, Laboratory Characteristics and Outcomes of Patients with Renal Versus Cardiac Light Chain Amyloidosis
          British Journal of Haematology
        • Shared and Unique Genomic Structural Variants of Different Histological Components within Testicular Germ Cell Tumours Identified with Mate Pair Sequencing
          Scientific Reports
        • Should Mucosal Bowel Invasion in Ovarian Cancer Be Assigned to FIGO Stage IV Disease?
          Gynecologic Oncology
        • Host Genetic Variation in the TNF and NF-ĸB Pathways and Overall Survival in Mantle Cell Lymphoma: A Discovery and Replication Study
          American Journal of Hematology
        • Sample Matrix and High-Sensitivity Cardiac Troponin I Assays
          Clinical Chemistry and Laboratory Medicine
        • Perinephric Myxoid Pseudotumor of Fat: A Distinctive Pseudoneoplasm Most Often Associated with Non-Neoplastic Renal Disease
          Human Pathology
        • Voiding Trial in Office after Unsuccessful Voiding Trial in Postoperative Unit. How Many More Days Is Enough?
          Journal of Minimally Invasive Gynecology
        • A National Survey of Radiation Oncologists and Urologists on Perceived Attitudes and Recommendations of Active Surveillance for Low-Risk Prostate Cancer
          Clinical Genitourinary Cancer
        • Accurate Patient-Specific Machine Learning Models of Glioblastoma Invasion Using Transfer Learning
          American Journal of Neuroradiology

Alyssa Frank

Alyssa Frank is a Marketing Segment Manager at Mayo Clinic Laboratories. She leads marketing strategies for product management and specialty testing. Alyssa has worked at Mayo Clinic since 2015.