Mayo Clinic Laboratory and Pathology Research Roundup: March 18

By Alyssa Frank • March 18, 2019

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The Research Roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Natural History of Multiple Myeloma with de novo del(17p)

Multiple myeloma is the second most common hematological malignancy and was expected to cause over 12,000 deaths in the United States in 2018. Translational research with introduction of proteasome inhibitors and immunomodulatory drugs and use of high-dose therapy with autologous stem cell transplant (ASCT) has consistently improved the outcomes in patients with multiple myeloma over the past two decades. Multiple myeloma is clinically and biologically heterogeneous and outcomes are influenced by a variety of factors including patient characteristics, tumor load, and disease biology, including the genomic abnormalities in malignant plasma cells (PCs). Recurrent cytogenetic abnormalities detected by interphase fluorescent in situ hybridization (FISH) on malignant PCs give key prognostic information. Deletion of short arm of chromosome 17 (17p13.1) is one of the adverse cytogenetic markers at diagnosis.

Published to PubMed This Week

• • • • • Identification of Key Challenges in Liver Pathology: Data from a Multicenter Study of Extramural Consults
          Human Pathology
        • Immunohistochemistry for TFE3 Lacks Specificity and Sensitivity in the Diagnosis of TFE3-Rearranged Neoplasms: A Comparative, Two-Laboratory Study
          Human Pathology
          
        • Updates in Spindle Cell/Pleomorphic Lipomas
          Seminars in Diagnostic Pathology
        • Corrigendum to "Clinical Significance of Coryneform Gram-Positive Rods from Blood Identified by MALDI-TOF Mass Spectrometry and Their Susceptibility Profiles—A Retrospective Chart Review"
          Diagnostic Microbiology and Infectious Disease
        • Subependymoma Involving Multiple Spinal Cord Levels: A Clinicopathological Case Series with Chromosomal Microarray Analysis
          Neuropathology
          
        • Clinical Use of Cardiac Troponin for Acute Cardiac Care and Emerging Opportunities in the Outpatient Setting
          Minerva Medica
        • Is Routine Hardware Removal Following Open Reduction Internal Fixation of Tarsometatarsal Joint Fracture/Dislocation Necessary?
          Journal of Foot and Ankle Surgery
        • Chemotherapy Scheduling Template Development Using an Optimization Approach
          International Journal of Health Care Quality Assurance
          
        • Comparison of the NCCN-IPI, the IPI and PIT Scores as Prognostic Tools in Peripheral T-cell Lymphomas
          British Journal of Haematology

Alyssa Frank

Alyssa Frank is a Marketing Segment Manager at Mayo Clinic Laboratories. She leads marketing strategies for product management and specialty testing. Alyssa has worked at Mayo Clinic since 2015.