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Diagnostic Molecular Pathology — Virtual Slides

Image File Presentation Case History
Case 3a Image Pre-Analytical Considerations: How to Get the Most Out of Tiny Biopsies and Cytology Specimens 55 F nonsmoker. Imaging suggests widely metastatic lung cancer. The oncologist orders transbronchial FNA and molecular testing.
Case 3b Image 78 M with left thigh melanoma and progressive disease in inguinal lymph nodes. The oncologist orders an ultrasound guided core biopsy and molecular testing.
Case 3c Image 75 M with colorectal cancer and liver mets. Oncologist requests image guided core biopsy of the liver and molecular testing.
Case 4a Image Biomarker Detection Using Immunohistochemistry: Interpretation and Regulation
Case 4b Image
Case 4c Image
Case 5a Image The Utility of Molecular Testing in Soft Tissue Pathology 55-year-old female with thigh mass.
Case 5b Image 40-year-old female with an abdominal wall mass.
Case 5c Image 20-year-old male with foot mass.
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Case 6b Image
Hereditary Disease
Case 7 Image RNA-Sequencing: A Powerful Tool for the Identification of Clinically Significant Gene Fusions in Sarcomas and Other Tumors
Case 9a Image Miscellaneous Pitfalls in Gynecological Pathology: Molecular Testing to the Rescue! 33 F missed abortion.
Case 9b Image 59 F multiple lung lesions.
Case 9c Image 50 F, AGUS Pap test. Tumor is seen in both the endometrial and endocervical curettage.
Case 10.1 Image Molecular Testing in Gynecologic Mesenchymal Tumors 26-year-old post-hysterectomy for uterine sarcoma; no adjuvant therapy; now with vaginal cuff lesion 2 months later.
Case 10.2a Image 51-year-old underwent resection of 4 cm vaginal mass.
Case 10.2b Image 49-year-old underwent hysterectomy for enlarging uterine mass.
Case 10.3a Image 63-year-old underwent hysterectomy for enlarging uterine mass.
Case 10.3b Image 56-year-old underwent hysterectomy for multiple uterine leiomyomas.
Case 10.3c Image 56-year-old underwent curettage for postmenopausal bleeding and a polypoid uterine mass.
Case 11a Image Molecular Classification of Endometrial Cancer:  Practical Concepts 75 F deeply invasive endometrial cancer with metastasis to para-aortic node.
Case 11b Image
Case 14 & 15 Image Diffuse Large B-Cell Lymphoma 47-year-old man with cervical lymphadenopathy.
Case 16a Image Hematopathology 66-year-old female presenting with weakness, fatigue, weight loss, and splenomegaly.
Case 16b Image 67-year-old female presenting with weakness, fatigue, weight loss, and splenomegaly.
Case 16c Image 68-year-old female presenting with weakness, fatigue, weight loss, and splenomegaly.
Case 16e Image 69-year-old female presenting with weakness, fatigue, weight loss, and splenomegaly.
Case 16f Image 70-year-old female presenting with weakness, fatigue, weight loss, and splenomegaly.
Case 16 Image 71-year-old female presenting with weakness, fatigue, weight loss, and splenomegaly.
Case 18 & 19a Image Lung Pathology A 67-year-old woman presents with a lung nodule that was discovered incidentally on a CT scan performed for cholecystitis. The nodule is a ground glass opacity measuring 1.2 cm, which has not appreciably changed during one year of follow-up. She is a never smoker. What driver mutation is most likely based on tumor morphology?
Case 18 & 19b Image A 74-year-old man with a 60 pack-year history of smoking presents with cough, and is found to have a 3.2 cm lung mass. What driver mutation is most likely based on tumor morphology?
Case 18 & 19c Image A 52-year-old woman presents with ataxia. Brain imaging shows multiple lesions worrisome for metastasis. PET CT reveals a 4.2 cm lung mass. What driver mutation is most likely based on tumor morphology?
Case 18 & 19d Image A 70-year-old man with an 80 pack-year smoking history presents with hemoptysis. Chest CT shows a 5.2 cm hilar lung mass. Based on the histology, what ancillary test is the patient’s oncologist most likely to be interested in?
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Case 21b Image
Case 21c Image
Molecular Pathology of Melanocytic Proliferation: A Brief Overview A 19-year-old male patient noticed a 4 mm pink papule on left ear (slightly above ear lobe). This papule has been there for over two years, and the patient felt it was slowly growing. There was no ulceration or bleeding. The lesion was not painful or itchy.
Case 22a Image
Case 22a Image
Molecular Diagnostics in Spindle Cell Lesions of the Breast 63-year-old female with 5 cm left breast mass.
Case 22b Image
Case 22b Image
Case 22b Image
66-year-old female with palpable, rapidly growing 2 cm right breast mass.
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Case 23a_3 Image
Molecular Pathology of “Triple-Negative Breast Carcinoma”: Case Illustrations 44-year-old female with palpable 2 cm left breast mass.
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Case 23b_2 Image
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Case 23b_4 Image
50-year-old female with 1.5 cm left breast mass identified on routine screening mammography.
Case 24 Image Neuropathology A 54-year-old man presented with mood and personality changes, and occasional black-out spells. MRIs of the brain revealed a tumor diffusely infiltrating the left frontal lobe and corpus callosum, harboring regions of heterogeneous post-contrast enhancement. The patient underwent an open biopsy of the tumor.
Case 25 Image Neuropathology A 7-year-old boy presented with intermittent episodes of vomiting and loss of consciousness. MRIs of the brain revealed a T2-hyperintense, bubbly-appearing mass in the right parieto-occipital lobe, which harbored nodular areas of post-contrast enhancement. The patient underwent tumor resection.
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