Mayo Clinic Laboratory and Pathology Research Roundup: April 15

By Alyssa Frank • April 15, 2019

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The Research Roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Molecular Approach to Diagnosis of Cardiovascular Implantable Electronic Device Infection

Sonicate fluid (SF), a solution derived from vortexing and sonication of explanted cardiovascular implantable electronic devices (CIED), is a higher-yield specimen compared to swabs or tissues for culture-based detection of microorganisms associated with CIED infection. Despite this, SF culture fails to identify a causative organism in ~50% of cases. We aimed to evaluate the diagnostic performance of 16S ribosomal RNA gene (rRNA) PCR/sequencing of SF and compare it to that of SF culture.

Published to PubMed This Week

• Spermatic Cord Liposarcoma
  Mayo Clinic Proceedings
• Paraneoplastic Cast Nephropathy Associated with Pancreatic Mixed Acinar-Neuroendocrine Carcinoma: A Case Report
  American Journal of Kidney Disorders
• Heavy Chain Fibrillary Glomerulonephritis: A Case Report
  American Journal of Kidney Disorders
• Using Computer Assisted Morphometrics of 5-Year Biopsies to Identify Biomarkers of Late Renal Allograft Loss
  American Journal of Transplant
• Body Mass Index, Mammographic Density, and Breast Cancer Risk by Estrogen Receptor Subtype
  Breast Cancer Research
• Cardiac Magnetic Resonance in Patients with Elevated Troponin and Normal Coronary Angiography
  Heart
• Carboxyl Ester Lipase May Not Mediate Lipotoxic Injury during Severe Acute Pancreatitis
  American Journal of Pathology
• Suboptimal Response Rates to Hypomethylating Agent Therapy in Chronic Myelomonocytic Leukemia; a Single Institutional Study of 121 Patient
  American Journal of Hematology
• Prognostic Value of Minimal Residual Disease and Polyclonal Plasma Cells in Myeloma Patients Achieving a Complete Response to Therapy
  American Journal of Hematology
• Adrenal Cortical Carcinoma Associated with Lynch Syndrome: A Case Report and Review of Literature
  Journal of the Endocrine Society
• Cold Storage of Porcine Hepatocyte Spheroids for Spheroid Bioartificial Liver
  Xenotransplantation
• An Expanded Variant List and Assembly Annotation Identifies Multiple Novel Coding and Noncoding Genes for Prostate Cancer Risk Using a Normal Prostate Tissue eQTL Data Set
  PLoS One
• A Comparison of Adult Rhabdomyosarcoma and High Grade Neuroendocrine Carcinoma of the Urinary Bladder Reveals Novel PPP1R12A Fusions in Rhabdomyosarcoma
  Human Pathology
• Oncocytoma Presenting as a Fat-Containing Intraparotid Mass
  Ear, Nose, Throat Jornal

Alyssa Frank

Alyssa Frank is a Marketing Segment Manager at Mayo Clinic Laboratories. She leads marketing strategies for product management and specialty testing. Alyssa has worked at Mayo Clinic since 2015.