Mayo Clinic Laboratory and Pathology Research Roundup: June 10

By Alyssa Frank • June 10, 2019

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The Research Roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Phase II Evaluation of Aggressive Dose De-Escalation for Adjuvant Chemoradiotherapy in Human Papillomavirus-Associated Oropharynx Squamous Cell Carcinoma

The purpose of this study was to determine if dose de-escalation from 60 to 66 Gy to 30 to 36 Gy of adjuvant radiotherapy (RT) for selected patients with human papillomavirus-associated oropharyngeal squamous cell carcinoma could maintain historical rates for disease control while reducing toxicity and preserving swallow function and quality of life (QOL).

Published to PubMed This Week

• Intrathecal Administration of Autologous Mesenchymal Stem Cells in Multiple System Atrophy
  Neurology
• Increasing Incidence and Mortality of Gastric Cancer in Immigrant Populations from High to Low Regions of Incidence - a Systematic Review and Meta-Analysis
  Clinical Gastroenterology and Hepatology
• Clinical and Histopathologic Features of Immune Checkpoint Inhibitor-related Pneumonitis
  American Journal of Surgical Pathology
• Increased Fecal Primary Bile Acids in Multiple Myeloma with Engraftment Syndrome Diarrhea After Stem Cell Transplant
  Bone Marrow Transplant
• Small-Cell Lung Cancer in Very Elderly (≥ 80 Years) Patients
  Clinical Lung Cancer
• Understanding Heterogeneous Tumor Microenvironment in Metastatic Melanoma
  PloS One
• Unlocking the Translational Potential of Circulating Nucleosomes for Liquid Biopsy in Diffuse Intrinsic Pontine Glioma
  Biomarkers in Medicine
• Intravascular Cardiac Lipoproteinosis: Extrarenal Manifestation of Lipoprotein Glomerulopathya
  Cardiovascular Pathology
• Targeted Opioid Screening Assay for Pain Management Using High-Resolution Mass Spectrometry
  Methods in Molecular Biology
• Simultaneous Determination of Tacrolimus and Cyclosporine A in Whole Blood by Ultrafast LC-MS/MS
  Methods in Molecular Biology
• Evaluating the Impact of Radiation Therapy on Patient Quality of Life Following Primary Artificial Urinary Sphincter Placement
  Translational Andrology and Urology
• Elucidating a false-negative MYC break-apart fluorescence in situ hybridization probe study by next-generation sequencing in a patient with high-grade B-cell lymphoma with IGH/MYC and IGH/BCL2 rearrangements
  Cold Spring Harbor Molecular Case Studies

Alyssa Frank

Alyssa Frank is a Marketing Segment Manager at Mayo Clinic Laboratories. She leads marketing strategies for product management and specialty testing. Alyssa has worked at Mayo Clinic since 2015.