Mayo Clinic Laboratory and Pathology Research Roundup: November 4

By Samantha Rossi • November 4, 2019

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Coexistence of Myelin Oligodendrocyte Glycoprotein and Aquaporin-4 Antibodies in Adult and Pediatric Patients.

Myelin oligodendrocyte glycoprotein (MOG)–IgG is a biomarker associated with central nervous system–demyelinating disorders termed MOG-IgG–associated disorders. These disorders have overlapping clinical features, including optic neuritis and myelitis, with aquaporin-4 (AQP4)–IgG–positive neuromyelitis optica spectrum disorders. These disorders are hypothesized to be biologically distinct; AQP4-IgG–positive neuromyelitis optica spectrum disorders are autoimmune astrocytopathies, whereas MOG-IgG–associated disorders are postulated to be autoimmune oligodendrocytopathies.¹ Despite their immunopathogenic differences, there are rare reports of patients with dual positivity of MOG-IgG and AQP4-IgG.^2,3 We aimed to determine the frequency, sex ratio, and coexistence of glial antibodies (AQP4-IgG and MOG-IgG) in adults and children undergoing evaluation for suspected central nervous system–demyelinating diseases. Via JAMA Neurology.

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Published to PubMed This Week

• Tau Deposition in Young Adults with Drug-Resistant Focal Epilepsy.
  Epilepsia
• Reply by Authors.
  Journal of Urology
• Predictors of Extensive Lymphatic Dissemination and Recurrences in Node-Positive Endometrial Cancer.
  Gynecologic Oncology
• Genes Associated with Bowel Metastases in Ovarian Cancer.
  Gynecologic Oncology
• Dissociating the Effects of Oxygen Pressure and Content on the Control of Breathing and Acute Hypoxic Response.
  Journal of Applied Physiology
• Treatment of Non-Obstructive, Non-Struvite Urolithiasis is Effective in Treatment of Recurrent Urinary Tract Infections.
  World Journal of Urology
• Optimizing Whole Brain Radiotherapy Dose and Fractionation: Results From A Prospective Phase III Trial (NCCTG N107C (Alliance)/CEC.3).
  International Journal of Radiation Oncology, Biology, and Physics
• Unusual Manifestations of Diffuse-Type Tenosynovial Giant Cell Tumor in Two Patients: Importance of Radiologic-Pathologic Correlation.
  Skeletal Radiology
• Severe Postoperative Hemorrhage in A Patient on Dietary and Herbal Supplements.
  Journal Preoperative Practice
• Prevalence of Clinically Significant Differences in Sodium Measurements Due to Abnormal Protein Concentrations Using an Indirect Ion-Selective Electrode Method.
  Journal of Applied Laboratory Medicine
• Evolution of Myeloma Testing in Clinical Chemistry with Mass Spectrometry.
  Journal of Applied Laboratory Medicine

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.