Mayo Clinic Laboratory and Pathology Research Roundup: January 20

By Samantha Rossi • January 20, 2020

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Fructose-1,6-Bisphosphatase Loss Modulates STAT3-Dependent Expression of PD-L1 and Cancer Immunity.

Abnormal expression of programmed death-1 (PD-1) ligand-1(PD-L1) in cancer cells plays a crucial role in cancer immune evasion and progression. The immune checkpoint molecules PD-1 and PD-L1 have been targeted for cancer treatment with significant benefits for cancer patients. However, the response rate is relatively low in certain types of cancer and the underlying mechanism remains poorly understood. Better understanding of the molecular mechanism of PD-L1 expression regulation in cancer cells is urgently needed to improve the treatment response rate and overall survival of patients. Fructose-1, 6-biphosphatase (FBP1) is a key enzyme in gluconeogenesis and is implicated in human cancer due to its frequent loss in various cancer types. Via Theranostics.

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Published to PubMed This Week

• High Level MYC Amplification in B-cell lymphomas: Is it a Marker of Aggressive Disease?
  Blood Cancer Journal
• Selective Intrarenal Delivery of Mesenchymal Stem Cell-Derived Extracellular Vesicles Attenuates Myocardial Injury in Experimental Metabolic Renovascular Disease.
  Basic Research in Cardiology
• Disseminated Blastomycosis Presenting as Obstructive Renal Mass Treated with Fluconazole.
  American Journal of Medicine
• Phenotypic Correlates and Prognostic Outcomes of TET2 Mutations in Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes: A Comprehensive Study of 504 Adult Patients.
  American Journal of Hematology
• Clinical Utility of Fluorescence In Situ Hybridization-based Diagnosis of BCR-ABL1 like (Philadelphia Chromosome like) B-Acute Lymphoblastic Leukemia.
  American Journal of Hematology
• Prediction of Nonalcoholic Fatty Liver Disease (NAFLD) Activity Score (NAS) with Multiparametric Hepatic Magnetic Resonance Imaging and Elastography.
  European Radiology
• Effect Modifiers of TDP-43 Associated Hippocampal Atrophy Rates in Patients with Alzheimer's Disease Neuropathological Changes.
  Journal of Alzheimers Diesease
• Cytotoxic T Cell Depletion with Increasing Epithelial Abnormality in Women with Benign Breast Disease.
  Breast Cancer Research and Treatment
• Uterine Inflammatory Myofibroblastic Tumors in Pregnant Women With and Without Involvement of the Placenta: A Study of Six Cases with Identification of a Novel TIMP3-RET Fusion.
  Human Pathology
• Long-Term Outcomes of Patients With Low Grade Cystic Renal Epithelial Neoplasms.
  Urology
• Nanoscale Structural Alterations in Cancer Cells to Assess Anti-Cancerous Drug Effectiveness in Ovarian Cancer Treatment Using TEM Imaging.
  Physical Biology
• Influence of High Affinity Haemoglobin on the Response to Normoxic and Hypoxic Exercise.
  Journal of Physiology
• An Open-Label Pilot Study of Adrenocorticotrophic Hormone in the Treatment of IgA Nephropathy at High Risk of Progression.
  Kidney International Reports

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.