Mayo Clinic Laboratory and Pathology Research Roundup: May 4

By Samantha Rossi • May 4, 2020

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Immune checkpoint inhibitor-induced thyroiditis is associated with increased intrathyroidal T lymphocyte subpopulations.

Immune checkpoint inhibitors (ICIs) frequently cause thyroid dysfunction but its underlying mechanism remains unclear. We have previously demonstrated increased circulating natural killer (NK) cells and HLA-DR surface expression on inflammatory intermediate CD14+CD16+ monocytes in programmed cell death protein-1 (PD-1) inhibitor treated patients. This study characterizes intrathyroidal and circulating immune cells and class II HLA in ICI-induced thyroiditis. Via Thyroid.

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Published to PubMed This Week

• Maternal T Cells in the Human Placental Villi Support an Allograft Response during Noninfectious Villitis.
  Journal of Immunology
• Cavernous Malformation Hemorrhagic Presentation at Diagnosis Associated with Low 25-Hydroxy-Vitamin D Level.
  Cerebrovascular Disease
• Routine HIV Test Results in 6 US Clinical Laboratories Using the Recommended Laboratory HIV Testing Algorithm With Geenius HIV 1/2 Supplemental Assay.
  Sexually Transmitted Disease
• Flow Cytometric Evaluation of TRBC1 Expression in Tissue Specimens and Body Fluids is a Novel and Specific Method for Assessment of T-Cell Clonality and Diagnosis of T-cell Neoplasms.
  Cytometry
• Novel Diagnostic Methods and Post Treatment Clinical Phenotypes Among Intracranial Germ Cell Tumors.
  Neurosurgery
• Cryptococcal Pneumonia in an Adolescent with a Gain-of-Function Variant in Signal Transduction and Activator of Transcription 1 (STAT1).
  BMJ Case Reports

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.