The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Immune checkpoint inhibitors (ICIs) frequently cause thyroid dysfunction but its underlying mechanism remains unclear. We have previously demonstrated increased circulating natural killer (NK) cells and HLA-DR surface expression on inflammatory intermediate CD14+CD16+ monocytes in programmed cell death protein-1 (PD-1) inhibitor treated patients. This study characterizes intrathyroidal and circulating immune cells and class II HLA in ICI-induced thyroiditis. Via Thyroid.