The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Immune checkpoint inhibitor-induced thyroiditis is associated with increased intrathyroidal T lymphocyte subpopulations.
Immune checkpoint inhibitors (ICIs) frequently cause thyroid dysfunction but its underlying mechanism remains unclear. We have previously demonstrated increased circulating natural killer (NK) cells and HLA-DR surface expression on inflammatory intermediate CD14+CD16+ monocytes in programmed cell death protein-1 (PD-1) inhibitor treated patients. This study characterizes intrathyroidal and circulating immune cells and class II HLA in ICI-induced thyroiditis. Via Thyroid.
Published to PubMed This Week
- Maternal T Cells in the Human Placental Villi Support an Allograft Response during Noninfectious Villitis.
Journal of Immunology
- Cavernous Malformation Hemorrhagic Presentation at Diagnosis Associated with Low 25-Hydroxy-Vitamin D Level.
- Routine HIV Test Results in 6 US Clinical Laboratories Using the Recommended Laboratory HIV Testing Algorithm With Geenius HIV 1/2 Supplemental Assay.
Sexually Transmitted Disease
- Flow Cytometric Evaluation of TRBC1 Expression in Tissue Specimens and Body Fluids is a Novel and Specific Method for Assessment of T-Cell Clonality and Diagnosis of T-cell Neoplasms.
- Novel Diagnostic Methods and Post Treatment Clinical Phenotypes Among Intracranial Germ Cell Tumors.
- Cryptococcal Pneumonia in an Adolescent with a Gain-of-Function Variant in Signal Transduction and Activator of Transcription 1 (STAT1).
BMJ Case Reports