Mayo Clinic Laboratory and Pathology Research Roundup: June 15

By Samantha Rossi • June 15, 2020

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Utility of FDG-PET in diagnosis of Alzheimer-related TDP-43 proteinopathy.

We conducted a cross-sectional neuroimaging-histologic analysis of patients with antemortem FDG-PET and postmortem brain tissue from the Mayo Clinic Alzheimer's Disease Research Center and Study of Aging with Alzheimer spectrum pathology. TDP-43-positive status was assigned when TDP-43-immunoreactive inclusions were identified in the amygdala. Statistical parametric mapping (SPM) analyses compared TDP-43-positive (TDP-43[+]) with TDP-43-negative cases (TDP-43[-]), correcting for field strength, sex, Braak neurofibrillary tangle, and neuritic plaque stages. Cross-validated logistic regression analyses were used to determine whether regional FDG-PET values predict TDP-43 status. We also assessed the ratio of inferior temporal to medial temporal (IMT) metabolism as this was proposed as a biomarker of hippocampal sclerosis. Via Neurology.

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Published to PubMed This Week

• Implementing High-Sensitivity Cardiac Troponin T in a US Regional Healthcare System.
  Circulation
• Landscape of RAS pathway mutations in patients with myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: a study of 461 molecularly annotated patients.
  Leukemia
• Can the SARS-CoV-2 PCR Cycle Threshold Value and Time from Symptom Onset to Testing Predict Infectivity?
  Clinical Infectious Disease
• Pyridoxine Responsiveness in a Type 1 Primary Hyperoxaluria Patient With a Rare (Atypical) AGXT Gene Mutation.
  Kidney International Reports
• Fibrolamellar Carcinoma.
  Mayo Clinic Proceedings
• Common Variable Immunodeficiency Enteropathy With Chronic Giardiasis.
  Mayo Clinic Proceedings
• Celiac disease: A subtle clue for a common disease.
  American Journal of Medicine
• Risk of Iodine Deficiency in Extremely Low Gestational Age Newborns on Parenteral Nutrition.
  Nutrients
• Performance Characteristics of Four High-Throughput Immunoassays for Detection of IgG Antibodies against SARS-CoV-2.
  Journal of Clinical Microbiology
• Letter to the Editor on "The 2018 Definition of Periprosthetic Hip and Knee Infection: An Evidence-Based and Validated Criteria".
  Journal of Arthroplasty
• Unintended Consequence of High-Dose Vitamin C Therapy for an Oncology Patient: Evaluation of Ascorbic Acid Interference With Three Hospital-Use Glucose Meters.
  Journal of Diabetes and Science Technology
• Mass spectrometry.
  Clinical Biochemistry
• Evaluation of Somatic Hypermutation Status in Chronic Lymphocytic Leukemia (CLL) in the Era of Next Generation Sequencing.
  Front Cell Developmental Biology
• Colonic Angiosarcoma Arising in Association with Amyloid Deposits.
  Case Reports in Gastrointestinal Medicine
• ASCL1-regulated DARPP-32 and t-DARPP Stimulate Small Cell Lung Cancer Growth and Neuroendocrine Tumour Cell Proliferation.
  British Journal of Cancer

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.