Mayo Clinic Laboratory and Pathology Research Roundup: June 22

By Samantha Rossi • June 22, 2020

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Early safety indicators of COVID-19 convalescent plasma in 5,000 patients.

Convalescent plasma is the only antibody-based therapy currently available for patients with coronavirus disease 2019 (COVID-19). It has robust historical precedence and sound biological plausibility. Although promising, convalescent plasma has not yet been shown to be safe as a treatment for COVID-19.METHODSThus, we analyzed key safety metrics after transfusion of ABO-compatible human COVID-19 convalescent plasma in 5000 hospitalized adults with severe or life-threatening COVID-19, with 66% in the intensive care unit, as part of the US FDA expanded access program for COVID-19 convalescent plasma. Via The Journal of Clinical Investigation.

Read more.

Published to PubMed This Week

• Myocardial Injury in Severe COVID-19 Infection.
  European Heart Journal
• Clinical Reasoning: Multifocal Neuropathies in a Patient with Waldenstrom Macroglobulinemia and Prior Borreliosis.
  Neurology
• Neoadjuvant Immunotherapy for Non-Small Cell Lung Cancer - Current Concepts and Future Approaches.
  Journal of Thoracic Oncology
• Semaphorin 3B-Associated Membranous Nephropathy is a Distinct Type of Disease Predominantly Present in Pediatric Patients.
  Kidney International
• ST-segment Elevation, Myocardial Injury, and Suspected or Confirmed COVID-19 Patients: Diagnostic and Treatment Uncertainties.
  Mayo Clinic Proceedings
• An International Phase 2 Study of Pazopanib in Progressive and Metastatic Thyroglobulin Antibody Negative Radioactive Iodine Refractory Differentiated Thyroid Cancer.
  Thyroid
• Acute Symptomatic Seizures Secondary to Autoimmune Encephalitis and Autoimmune-Associated Epilepsy: Conceptual Definitions.
  Epilepsia
• Laboratory Monitoring of Patients with Hereditary Tyrosinemia Type I.
  Molecular Genetics and Metabolism
• Potential Differences Between Monolingual and Bilingual Patients in Approach and Outcome After Awake Brain Surgery.
  Journal of Neurooncology
• Double Seropositivity for AChR and MuSK Autoantibodies in Myasthenia Gravis.
  Neuromuscular Disorder
• Concordance Between Predicted HLA Type Using Next Generation Sequencing Data Generated for Non-HLA Purposes and Clinical HLA Type.
  Human Immunology
• Pancreatic Endocrine Heterotopia Involving Meckel's Diverticulum: A Potential Mimic of Neuroendocrine Tumor.
  International Journal of Surgical Pathology
• Treatment Effectiveness and Medication Use Reduction for Older Adults in Interdisciplinary Pain Rehabilitation.
  Mayo Clinic Proceedings
• Improved Recognition of 25-Hydroxyvitamin D2 by 2 Automated Immunoassays.
  Journal of Applied Laboratory Medicine
• A Review of Cardiac Complications in Coronavirus Disease 2019.
  Cureus

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.