Mayo Clinic Laboratory and Pathology Research Roundup: August 24

By Samantha Rossi • August 24, 2020

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Patterns of Cancer Progression of Metastatic Hormone-sensitive Prostate Cancer in the ECOG3805 CHAARTED Trial.

ECOG3805 is a randomized trial of testosterone suppression with or without docetaxel for metastatic hormone-sensitive prostate cancer (mHSPC). Deeper prostate-specific antigen (PSA) suppression is prognostic for outcome. However, the concordance of PSA rise and radiographic progression has not been examined previously in mHSPC, whereas this has been reported in metastatic castration-resistant prostate cancer. Via European Urology Oncology.

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Published to PubMed This Week

• Two-stage Study of Familial Prostate Cancer by Whole-exome Sequencing and Custom Capture Identifies 10 Novel Genes Associated with the Risk of Prostate Cancer.
  European Urology Oncology
• Neurological Autoimmunity and Immune Checkpoint Inhibitors: Autoantibody Profiles and Outcomes.
  Neurology
• College of American Pathologists (CAP) Microbiology Committee Perspective: Caution must be used in Interpreting the Cycle Threshold (Ct) Value.
  Clinical Infectious Disease
• Cytogenetic Abnoalities in Multrmiple Myeloma: Association with Disease Characteristics and Treatment Response.
  Blood Cancer Journal
• Chronic Graft-Versus-Host Disease in Pancreas After Kidney Transplant Recipients - An Unrecognized Entity.
  American Journal of Transplants
• Cardiac and Respiratory Complications of Necrotizing Autoimmune Myopathy.
  Mayo Clinic Proceedings
• Guillain-Barré Syndrome in a Patient With Evidence of Recent SARS-CoV-2 Infection.
  Mayo Clinic Proceedings
• Seasonality of Coronavirus 229E, HKU1, NL63, and OC43 From 2014 to 2020.
  Mayo Clinic Proceedings
• Provision of a Drug Deactivation System for Unused Opioid Disposal at Surgical Dismissal: Opportunity to Reduce Community Opioid Supply.
  Mayo Clinic Proceedings
• Impact of Interatrial Shunts on Invasive Hemodynamics and Exercise Tolerance in Patients With Heart Failure.
  Journal of American Heart Association

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.