Mayo Clinic Laboratory and Pathology Research Roundup: August 31

By Samantha Rossi • August 31, 2020

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Nanomaterial-Based Therapeutics for Antibiotic-Resistant Bacterial Infections.

Antibiotic-resistant bacterial infections arising from acquired resistance and/or through biofilm formation necessitate the development of innovative 'outside of the box' therapeutics. Nanomaterial-based therapies are promising tools to combat bacterial infections that are difficult to treat, featuring the capacity to evade existing mechanisms associated with acquired drug resistance. In addition, the unique size and physical properties of nanomaterials give them the capability to target biofilms, overcoming recalcitrant infections. In this Review, we highlight the general mechanisms by which nanomaterials can be used to target bacterial infections associated with acquired antibiotic resistance and biofilms. We emphasize design elements and properties of nanomaterials that can be engineered to enhance potency. Lastly, we present recent progress and remaining challenges for widespread clinical implementation of nanomaterials as antimicrobial therapeutics. Via Nature Reviews. Microbiology.

Read more.

Published to PubMed This Week

• Effect of Genotype-Guided Oral P2Y12 Inhibitor Selection vs Conventional Clopidogrel Therapy on Ischemic Outcomes After Percutaneous Coronary Intervention: The TAILOR-PCI Randomized Clinical Trial.
  JAMA
• KRAS controls pancreatic cancer cell lipid metabolism and invasive potential through the lipase HSL.
  Cancer Research
• Efficacy of Rituximab and Plasma Exchange in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis with Severe Renal Disease.
  Journal of American Society of Nephrology
• Immunotactoid glomerulopathy is a rare entity with monoclonal and polyclonal variants.
  Kidney International
• Limited diagnostic impact of duplications <1 Mb of uncertain clinical significance: a 10-year retrospective analysis of reporting practices at the Mayo Clinic.
  Genetic Medicine
• Challenges and Controversies Related to Testing for COVID-19.
  Journal of Clinical Microbiology
• Malignant Peritoneal Mesothelioma Arising in Young Adults With Long-standing Indwelling Intra-abdominal Shunt Catheters.
  American Journal of Surgical Pathology
• Therapeutic plasma exchange clears circulating soluble PD-L1 and PD-L1-positive extracellular vesicles.
  Journal of Immunotherapy Cancer
• Characterization of the Progression from Ambulatory to Hospitalized Heart Failure with Preserved Ejection Fraction.
  Journal of Cardiac Failure
• Robotic laparoendoscopic single-site (LESS) and reduced port hysterectomy using the da Vinci SP® Surgical System: a single institution case series.
  Journal of Minimal Invasive Gynecology

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.