Mayo Clinic Laboratory and Pathology Research Roundup: September 28

By Samantha Rossi • September 28, 2020

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Cardiac Troponin for Assessment of Myocardial Injury in COVID-19: JACC Review Topic of the Week.

Increases in cardiac troponin indicative of myocardial injury are common in patients with coronavirus disease-2019 (COVID-19) and are associated with adverse outcomes such as arrhythmias and death. These increases are more likely to occur in those with chronic cardiovascular conditions and in those with severe COVID-19 presentations. The increased inflammatory, prothrombotic, and procoagulant responses following severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection increase the risk for acute nonischemic myocardial injury and acute myocardial infarction, particularly type 2 myocardial infarction, because of respiratory failure with hypoxia and hemodynamic instability in critically ill patients. Myocarditis, stress cardiomyopathy, acute heart failure, and direct injury from SARS-CoV-2 are important etiologies, but primary noncardiac conditions, such as pulmonary embolism, critical illness, and sepsis, probably cause more of the myocardial injury. The structured use of serial cardiac troponin has the potential to facilitate risk stratification, help make decisions about when to use imaging, and inform stage categorization and disease phenotyping among hospitalized COVID-19 patients. Via Journal of the American College of Cardiology.

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Published to PubMed This Week

• Uncommon Cause of Emesis and Diarrhea in a Non-verbal Elderly Patient.
  Gastroenterology
• Neutralizing Antibody and Soluble ACE2 Inhibition of a Replication-Competent VSV-SARS-CoV-2 and a Clinical Isolate of SARS-CoV-2.
  Cell Host and Microbe
• Larger Nephron Size and Nephrosclerosis Predict Progressive CKD and Mortality after Radical Nephrectomy for Tumor and Independent of Kidney Function.
  Journal of American Society Nephrology
• Improving Accuracy of Myasthenia Gravis Autoantibody Testing by Reflex Algorithm.
  Neurology
• Inference from Longitudinal Laboratory Tests Characterizes Temporal Evolution of COVID-19-Associated Coagulopathy (CAC).
  Elife
• Response to Letter to the Editor: "Real-World Considerations for Applicability of Text Message Interventions for Promotion of Physical Activity".
  American Journal of Preventative Medicine
• Evaluation of the MC4R Gene Across eMERGE Network Identifies Many Unreported Obesity-Associated Variants.
  International Journal of Obesity
• The Brief Case: What a Fluke! A Case of Fascioliasis with Pulmonary Involvement in a Peace Corps Volunteer.
  Journal of Clinical Microbiology
• Closing the Brief Case: What a Fluke! A Case of Fascioliasis with Pulmonary Involvement in a Peace Corps Volunteer.
  Journal of Clinical Microbiology
• Incidental Richter Transformation in Chronic Lymphocytic Leukemia Patients During Temporary Interruption of Ibrutinib.
  Blood Advances

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.