Mayo Clinic Laboratory and Pathology Research Roundup: October 19

By Samantha Rossi • October 19, 2020

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Novel Methylated DNA Markers in the Surveillance of Colorectal Cancer Recurrence.

Of the 14 selected MDMs, the concordance between primary and metastatic tissue was considered moderate or higher for 12 MDMs (86%). At a preset specificity of 95% (91-98%), a panel of 13 MDMs in plasma from 97 CRC cases and 200 controls detected stage IV CRC with 100% (80-100%) sensitivity and all stages of CRC with an AUC 0.91 (0.87-0.95), significantly higher than CEA (AUC 0.72 (0.65-0.79)). This panel in plasma from 40 cases, and 60 healthy controls detected recurrent/metastatic CRC with 90% (76-97%) sensitivity with specificity of 90% (79-96%) and an AUC of 0.96 (0.92-1).The panel was positive in 0.30 (0.19-0.43) of 60 patients with no evidence of disease post-operative CRC patients. Via Clinical Cancer Research

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Published to PubMed This Week

• Effect of Germline Mutations in Homologous Recombination Repair Genes on Overall Survival of Patients with Pancreatic Adenocarcinoma.
  Clinical Cancer Research
• Changing Paradigms in Diagnosis and Treatment of Monoclonal Gammopathy of Undetermined Significance (MGUS) and Smoldering Multiple Myeloma (SMM).
  Leukemia
• Utility of T-Cell Receptor β Constant Chain-1 Expression in the Diagnosis of Peripheral Blood Involvement by Cutaneous T-Cell Lymphoma.
  Journal of Investigative Dermatology
• Letter: A Retrospective Comparative Analysis of Titanium Mesh and Custom Implants for Cranioplasty.
  Neurosurgery
• Medical Parasitology Taxonomy Update, January 2018-May 2020.
  Journal of Clinical Microbiology
• Pain Catastrophizing as a Treatment Process Variable in Cognitive Behavioral Therapy for Adults with Chronic Pain.
  European Journal of Pain
• Transition from Room-Temperature to Cold-Stored Platelets for the Preservation of Blood Inventories during the COVID-19 Pandemic.
  Transfusion
• Biopsies of Hepatocellular Carcinoma with no Reticulin Loss: An Important Diagnostic Pitfall.
  Human Pathology
• Immune Dysfunction in MGAT2-CDG: A Clinical Report and Review of the Literature.
  American Journal of Medicine and Genetics
• International Medical Graduates are Comparable to American Medical Graduates as General Surgery Interns.
  Journal of Surgical Research

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.