Mayo Clinic Laboratory and Pathology Research Roundup: October 19
The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Of the 14 selected MDMs, the concordance between primary and metastatic tissue was considered moderate or higher for 12 MDMs (86%). At a preset specificity of 95% (91-98%), a panel of 13 MDMs in plasma from 97 CRC cases and 200 controls detected stage IV CRC with 100% (80-100%) sensitivity and all stages of CRC with an AUC 0.91 (0.87-0.95), significantly higher than CEA (AUC 0.72 (0.65-0.79)). This panel in plasma from 40 cases, and 60 healthy controls detected recurrent/metastatic CRC with 90% (76-97%) sensitivity with specificity of 90% (79-96%) and an AUC of 0.96 (0.92-1).The panel was positive in 0.30 (0.19-0.43) of 60 patients with no evidence of disease post-operative CRC patients. Via Clinical Cancer Research
Published to PubMed This Week
- Effect of Germline Mutations in Homologous Recombination Repair Genes on Overall Survival of Patients with Pancreatic Adenocarcinoma.
Clinical Cancer Research
- Changing Paradigms in Diagnosis and Treatment of Monoclonal Gammopathy of Undetermined Significance (MGUS) and Smoldering Multiple Myeloma (SMM).
- Utility of T-Cell Receptor β Constant Chain-1 Expression in the Diagnosis of Peripheral Blood Involvement by Cutaneous T-Cell Lymphoma.
Journal of Investigative Dermatology
- Letter: A Retrospective Comparative Analysis of Titanium Mesh and Custom Implants for Cranioplasty.
- Medical Parasitology Taxonomy Update, January 2018-May 2020.
Journal of Clinical Microbiology
- Pain Catastrophizing as a Treatment Process Variable in Cognitive Behavioral Therapy for Adults with Chronic Pain.
European Journal of Pain
- Transition from Room-Temperature to Cold-Stored Platelets for the Preservation of Blood Inventories during the COVID-19 Pandemic.
- Biopsies of Hepatocellular Carcinoma with no Reticulin Loss: An Important Diagnostic Pitfall.
- Immune Dysfunction in MGAT2-CDG: A Clinical Report and Review of the Literature.
American Journal of Medicine and Genetics
- International Medical Graduates are Comparable to American Medical Graduates as General Surgery Interns.
Journal of Surgical Research