Mayo Clinic laboratory and pathology research roundup: December 28

By Samantha Rossi • December 28, 2020

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Improving accuracy of myasthenia gravis autoantibody testing by reflex algorithm.

Myasthenia gravis (MG) serologic tests with confirmatory or refuting clinical-electrodiagnostic (EDX) testing and cancer evaluations were reviewed over 4 years (2012-2015). All patients had acetylcholine receptor-binding (AChR-Bi), modulating (AChR-Mo), and striational (STR) autoantibody testing, and negatives reflexed to muscle-specific kinase (MuSK). Thymoma and cancer occurrences were correlated with STR and reflexed glutamic acid decarboxylase 65 (GAD65), ganglionic acetylcholine receptor (α3), collapsin response mediating protein-5, and voltage-gated potassium channel complex autoantibodies. Via Neurology

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Published to PubMed This Week

• A Broad-Based Submucosal Polyp.
  Gastroenterology
• Decrease in Enteroviral Meningitis - An Unexpected Benefit of COVID-19 Mitigation?
  Clinical Infectious Disease
• Prognostic variables in low and high risk stage III colon cancers treated in two adjuvant chemotherapy trials.
  European Journal of Cancer
• Progesterone receptor isoform-dependent cross-talk between prolactin and fatty acid synthase in breast cancer.
  Aging
• Novel methylated DNA markers accurately discriminate Lynch syndrome associated colorectal neoplasia.
  Epigenoimics
• Multicenter Evaluation of the Unyvero Platform for Testing Bronchoalveolar Lavage Fluid.
  Journal of Clinical Microbiology
• Measurement of apolipoprotein B levels helps in the identification of patients at risk for hypertriglyceridemic pancreatitis.
  Journal of Clinical Lipidology
• Influence of primary payer status on the management and outcomes of ST-segment elevation myocardial infarction in the United States.
  PLoS One
• Cytoplasmic Expression of CD3ε Heterodimers by Flow Cytometry Rapidly Distinguishes Between Mature T-Cell and Natural Killer-Cell Neoplasms.
  American Journal of Clinical Pathology
• An In Silico Exploration of the Factors That Affect the Precision of the Bethesda Assay.
  American Journal of Clinical Pathology

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.