Mayo Clinic laboratory and pathology research roundup: March 2

By Samantha Rossi • March 2, 2021

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

ROBUST: A phase III study of lenalidomide plus R-CHOP versus placebo plus R-CHOP in previously untreated patients With ABC-type diffuse large b-cell lymphoma.

Patients with the activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) historically showed inferior survival with standard rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP). Phase II studies demonstrated that adding the immunomodulatory agent lenalidomide to R-CHOP improved outcomes in ABC-type DLBCL. The goal of the global, phase III ROBUST study was to compare lenalidomide plus R-CHOP (R2-CHOP) with placebo/R-CHOP in previously untreated, ABC-type DLBCL. Via Journal of Clinical Oncology

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Published to PubMed This Week

• Adjusting the MI codes into the framework of the universal definition of myocardial infarction.
  Journal of the American College of Cardiology
• Strong functional data for pathogenicity or neutrality classify BRCA2 DNA-binding-domain variants of uncertain significance.
  American Journal of Human Genetics
• Inhibition of ATM induces hypersensitivity to proton irradiation by upregulating toxic end joining.
  Cancer Research
• GAS7 deficiency promotes metastasis in MYCN-driven neuroblastoma.
  Cancer Research
• Disease monitoring with quantitative serum IgA levels provides a more reliable response assessment in multiple myeloma patients.
  Leukemia
• Discordance rate among bilateral simultaneous and sequential temporal artery biopsies in giant cell arteritis: Role of frozen sectioning based on the Mayo Clinic experience.
  JAMA Ophthalmologist
• Extreme thrombocytosis in low-risk essential thrombocythemia: retrospective review of vascular events and treatment strategies.
  American Journal of Hematology
• Malignant peritoneal mesothelioma arising in young adults with long-standing indwelling intra-abdominal shunt catheters.
  American Journal of Surgical Pathology
• Amyloid-like fibronectin deposits in the liver: A novel morphologic finding.
  American Journal of Surgical Pathology
• Heterogeneity of PD-L1 expression between invasive and lepidic components of lung adenocarcinomas.
  Cancer Immunology and Immunotherapy

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.