Mayo Clinic laboratory and pathology research roundup: April 6

By Samantha Rossi • April 6, 2021

Share this:

The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Convalescent plasma antibody levels and the risk of death from Covid-19.

In a retrospective study based on a U.S. national registry, we determined the anti-SARS-CoV-2 IgG antibody levels in convalescent plasma used to treat hospitalized adults with Covid-19. The primary outcome was death within 30 days after plasma transfusion. Patients who were enrolled through July 4, 2020, and for whom data on anti-SARS-CoV-2 antibody levels in plasma transfusions and on 30-day mortality were available were included in the analysis. Via New England Journal of Medicine.

Read more.

Published to PubMed This Week

• Mutations in BRCA1/2 and other panel genes in patients with metastatic breast cancer -association with patient and disease characteristics and effect on prognosis.
  Journal of Clinical Oncology
• Kidney injury and disease in patients with haematological malignancies.
  Nature Reviews. Nephrology
• Strong functional data for pathogenicity or neutrality classify BRCA2 DNA-binding-domain variants of uncertain significance.
  American Journal of Human Genetics
• Mutated SPOP E3 ligase promotes 17βHSD4 protein degradation to drive androgenesis and prostate cancer progression.
  Cancer Research
• Immunofluorescence staining for immunoglobulin heavy chain/light chain on kidney biopsies is a valuable ancillary technique for the diagnosis of monoclonal gammopathy-associated kidney diseases.
  Kidney International
• Commentary on unexpected presence of an unusual opioid in a patient with chronic pain.
  Clinical Chemistry
• Hypomagnesemia at the time of autologous stem cell transplantation for patients with diffuse large B-cell lymphoma is associated with an increased risk of failure.
  Blood Cancer Journal
• Musicogenic epilepsy: Expanding the spectrum of glutamic acid decarboxylase 65 neurological autoimmunity.
  Epilepsia
• Anticipatory human subthalamic area beta-band power responses to dissociable tastes correlate with weight gain.
  Neurobiology Disease
• Reactive eosinophil proliferations in tissue and the lymphocytic variant of hypereosinophilic syndrome.
  American Journal of Clinical Pathology

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.