Mayo Clinic laboratory and pathology research roundup: April 20

By Samantha Rossi • April 20, 2021

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Protocadherin 7-associated membranous nephropathy.

We performed laser microdissection and mass spectrometry (MS/MS) in kidney biopsies from 135 individuals with PLA2R-negative MN, and used immunohistochemistry/immunofluorescence and confocal microscopy to confirm the MS/MS finding, detect additional cases, and localize the novel protein. We also performed MS/MS and immunohistochemistry on 116 controls and used immunofluorescence microscopy to screen biopsy samples from two validation cohorts. Western blot and elution studies were performed to detect antibodies in serum and biopsy tissue. Via Journal of American Society of Nephrology.

Read more.

Published to PubMed This Week

• Levosimendan improves hemodynamics and exercise tolerance in PH-HFpEF: Results of the randomized placebo-controlled HELP trial.
  JACC Heart Failure
• The clinical impact of proteomics in amyloid typing.
  Mayo Clinic Proceedings
• Adherence to public health measures mitigates the risk of COVID-19 infection in older adults: A community-based study.
  Mayo Clinic Proceedings
• Venetoclax with azacitidine or decitabine in blast-phase myeloproliferative neoplasm: a multicenter series of 32 consecutive cases.
  American Journal of Hematology
• Predatory conferences: Calling for vigilance from ophthalmologists and vision scientists.
  American Journal of Ophthalmology
• The combination of venetoclax and ixazomib selectively and efficiently kills HIV infected cell lines, but has unacceptable toxicity in primary cell models.
  Journal of Virology
• The American Society of Colon and Rectal surgeons clinical practice guidelines for the surgical management of ulcerative colitis.
  Diseases of Colon and Rectum
• Randomized phase II trial of capecitabine and lapatinib with or without IMC-A12 (Cituxumumab) in patients with HER2-positive advanced breast cancer previously treated with trastuzumab and chemotherapy: NCCTG N0733 (Alliance).
  Breast Cancer Research Treatment
• Bicarbonate ion transport by the electrogenic Na⁺ /HCO₃ ^- cotransporter, NBCe1, is required for normal electrical slow-wave activity in mouse small intestine.
  Neurogastroenterology and Motility
• Natural history of nasal vestibulitis associated with paclitaxel, docetaxel, and other chemotherapy agents: a Minnesota Cancer Clinical Trials Network (MNCCTN) study.
  Supportive Care in Cancer

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.