Mayo Clinic laboratory and pathology research roundup: June 15

By Samantha Rossi • June 15, 2021

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Senolytics reduce coronavirus-related mortality in old mice. 

The COVID-19 pandemic has revealed the pronounced vulnerability of the elderly and chronically-ill to SARS-CoV-2-induced morbidity and mortality. Cellular senescence contributes to inflammation, multiple chronic diseases, and age-related dysfunction, but effects on responses to viral infection are unclear. Here, we demonstrate that senescent cells (SnC) become hyper-inflammatory in response to pathogen-associated molecular patterns (PAMPs), including SARS-CoV-2 Spike protein-1, increasing expression of viral entry proteins and reducing anti-viral gene expression in non-SnCs through a paracrine mechanism. Via Science

Read more.

Published to PubMed This Week

• Risk of breast cancer among carriers of pathogenic variants in breast cancer predisposition genes varies by polygenic risk score. 
  Journal of Clinical Oncology
• Raising the bar for clinical cardiac troponin research studies and implementation science. 
  Circulation
• A molecular pathology, neurobiology, biochemical, genetic and neuroimaging study of progressive apraxia of speech. 
  Nature Communications
• Correction: MASS-FIX for the detection of monoclonal proteins and light chain N-glycosylation in routine clinical practice: a cross-sectional study of 6315 patients.
  Blood Cancer Journal
• Diagnostic challenges of focal nodular hyperplasia: Interobserver variability, accuracy, and the utility of glutamine synthetase immunohistochemistry. 
  Histopathology
• Primary renal well-differentiated neuroendocrine tumor (Carcinoid) in a horseshoe kidney. 
  Mayo Clinic Proceedings
• Treatment of AL Amyloidosis: Mayo stratification of myeloma and risk-adapted therapy (mSMART) consensus statement 2020 update. 
  Mayo Clinic Proceedings
• Group III phospholipase A2 downregulation attenuated survival and metastasis in ovarian cancer and promotes chemo-sensitization. 
  Journal of Experimental and Clinical Cancer Research
• Comparative transcriptomic analysis of staphylococcus aureus associated with periprosthetic joint infection under in vivo and in vitro conditions. 
  Journal of Molecular Diagnosis
• Synovial fluid α defensin has comparable accuracy to synovial fluid white blood cell count and polymorphonuclear percentage for periprosthetic joint infection diagnosis. 
  Bone and Joint Journal

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.