Impact of pre-analytical variables on clinical laboratory testing and patient care


This "Phlebotomy Webinar" presentation highlights the most common pre-analytical variables encountered in the hospital setting that may compromise blood specimen integrity and lead to specimen recollection. It also describes strategies and tools available to detect pre-analytical errors and reduce sample rejection.



Brooke Katzman profile

Brooke Katzman, Ph.D.

Assistant Professor of Laboratory Medicine and Pathology
Department of Laboratory Medicine and Pathology
Mayo Clinic, Rochester, Minnesota

Learning objectives

Upon completion of this activity, participants should be able to:

  • List the pre-analytical variables commonly encountered in laboratory medicine.
  • Identify the nature and frequency of pre-analytical factors responsible for sample rejection.
  • Describe effective strategies to reduce the rate of specimen rejection and mitigate the risk of patient harm.

Intended audience

This series is appropriate for phlebotomists, phlebotomy managers, phlebotomy educators, and other patient-care staff involved in specimen collection.


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This post was developed by our Education and Technical Publications Team.