Mayo Clinic laboratory and pathology research roundup: June 29

By Samantha Rossi • June 29, 2021

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

MAP3K7-IKK inflammatory signaling modulates AR protein degradation and prostate cancer progression.

Androgen receptor (AR) is a major survival factor for prostate cancer (PCa). Inflammation is implicated in many cancer types including PCa. Activation of MAP3K7 (also termed TAK1) and downstream IκB kinase β (IKKβ) by pro-inflammatory cytokines such as TNFα stimulates NF-κB survival pathways. Paradoxically, MAP3K7 is often deleted in human PCa. Here we demonstrate that AR protein expression is lower in inflammatory tumor areas compared to non-inflammatory tissues in PCa patients. Via Cancer Research

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Published to PubMed This Week

• Renal neoplasia in tuberous sclerosis: A study of 41 patients.
  Mayo Clinic Proceedings
• Treatment of AL amyloidosis: Mayo stratification of myeloma and risk-adapted therapy (mSMART) consensus statement 2020 update.
  Mayo Clinic Proceedings
• Primary renal well-differentiated neuroendocrine tumor (carcinoid) in a horseshoe kidney.
  Mayo Clinic Proceedings
• Pediatric hepatocellular adenomas: The influence of age and syndrome on subtype.
  American Journal of Surgical Pathology
• IA bodybuilder with dyspnea and hypercalcemia.
  American Journal Medicine
• Activity of lysin CF-296 alone and in addition to daptomycin in a rat model of experimental methicillin-resistant staphylococcus aureus osteomyelitis.
  Antimicrobial Agents and Chemotherapy
• Practical development and operationalization of a 12-hour hospital census prediction algorithm.
  JAMIA
• Effects of the ABCB1 c.3435C>T (rs1045642) polymorphism on heat pain perception in opioid-free adults with chronic pain.
  Anesthesia and Analgesia
• Association of mammographic density measures and breast cancer "intrinsic" molecular subtypes.
  Breast Cancer Research and Treatment
• A systematic review supporting the society for vascular surgery guidelines on the management of carotid artery disease.
  Journal of Vascular Surgery

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.