Kelch-like protein 11 autoantibodies: A novel biomarker of testicular cancer-associated neurological autoimmunity


Specialty Webinar

Expires: July 22, 2022

Originally presented July 22nd and 23rd, 2021

Presentation recording coming soon!

Overview

This “Specialty Testing” webinar will discuss the collaborative effort that led to the discovery of Kelch-like protein 11 (KLHL11) IgG as a specific biomarker of neurological autoimmunity-associated testicular germ cell tumors. Recognizing these clinical and radiological features of KLHL11 autoimmunity can avoid delays in diagnosis. Insights into the etiopathogenic mechanism of this cytotoxic-T cell-mediated syndrome may help with formulation of therapeutic strategies. Furthermore, understanding the diagnostic potential and limitations of KLHL11 IgG detection assays may aid the managing clinicians in optimal test interpretation.

Presenter

Divyanshu Dubey, M.B.B.S., portrait square

Divyanshu Dubey, M.B.B.S.

Assistant Professor of Laboratory Medicine and Pathology and Neurology
Division of Clinical Biochemistry
Mayo Clinic, Rochester, Minnesota

Learning objectives

Upon completion of this activity, participants should be able to:

  • Recognize novel paraneoplastic syndrome associated with testicular germ cell tumors 
  • Review techniques utilized for autoantigen discovery 
  • Review immunopathological data providing insight into KLHL11 encephalitis pathogenesis

Intended audience

This webinar is designed for any provider who sees patients with neurologic diseases (e.g., neurologists, psychiatrists, and primary care physicians, including internists and family care practitioners) as well as pathologists, laboratory directors, and laboratory send-out coordinators.

Credit

The following types of credit are offered for this event:

ASCLS P.A.C.E.®

Mayo Clinic Laboratories is approved as a provider of continuing education programs in the Clinical Laboratory Sciences by the ASCLS P.A.C.E.® program. This program has been approved for a maximum of 1.0 P.A.C.E.® contact hour.

State of California

Mayo Clinic Laboratories is approved as a Continuing Education Accrediting Agency for Clinical Laboratory Sciences for the State of California. This program has been approved for 1.0 contact hour.

State of Florida

Mayo Clinic Laboratories is approved as a Continuing Education Accrediting Agency for the Clinical Laboratory Sciences for the State of Florida. Florida Board of Clinical Laboratory Personnel has designated this program for General credit. This program has been approved for 1.0 contact hour.

To obtain credit


1. Register for and participate in the program.

2. Complete the evaluation that will be sent to you after the program.

3. Generate and print your certificate(s).

Level of instruction for this program is intermediate.

Faculty disclosure


Course director(s), planning committee, faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity. Safeguards against commercial bias have been put in place. Faculty members also will disclose any off-label and/or investigational use of pharmaceuticals or instruments discussed in their presentations. Disclosure of this information will be published in course materials so those participants in the activity may formulate their own judgments regarding the presentations.

Learn more about our testing

Questions?

Contact us: mcleducation@mayo.edu

MCL Education (@mmledu)

MCL Education

This post was developed by our Education and Technical Publications Team.