Mayo Clinic Laboratory and pathology research roundup: August 17

By Chantell Canfield • August 17, 2021

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Therapeutic anticoagulation with heparin in noncritically ill patients with COVID-19.

Thrombosis and inflammation may contribute to the risk of death and complications among patients with coronavirus disease 2019 (Covid-19). We hypothesized that therapeutic-dose anticoagulation may improve outcomes in noncritically ill patients who are hospitalized with Covid-19. Via PubMed

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Published to PubMed This Week

• Genetic insights into biological mechanisms governing human ovarian ageing.
  Nature
• Human TBK1 deficiency leads to autoinflammation driven by TNF-induced cell death.
  Cell
• Prognostically relevant periprocedural myocardial injury and infarction associated with percutaneous coronary interventions: a consensus document of the ESC working group on cellular biology of the heart and European association of percutaneous cardiovascular interventions (EAPCI).
  European Heart Journal
• Exercise-induced angiogenesis is dependent on metabolically primed ATF3/4⁺ endothelial cells.
  Cell Metabolism
• Cell fate conversion prediction by group sparse optimization method utilizing single-cell and bulk OMICs data.
  Briefings in Bioinformatics
• A mass spectrometry-based targeted assay for detection of SARS-CoV-2 antigen from clinical specimens.
  EBioMedicine
• Assessment of opioid use and analgesic requirements after endoscopic sinus surgery: A randomized clinical trial.
  JAMA Otolaryngol Head and Neck Surgery
• The need for dedicated microbiology leadership in the clinical microbiology laboratory.
  Journal of Clinical Microbiology
• Fisetin for COVID-19 in skilled nursing facilities (COVID-FIS): senolytic trials in the COVID era.
  Journal of The American Geriatrics Society
• Aneurysmal bone cyst with an unusual clinical presentation and a novel VDR-USP6 fusion.
  Genes, Chromosomes and Cancer

Chantell Canfield

Chantell Canfield is a web content coordinator for Mayo Clinic Laboratories. She began working for Mayo Clinic in 2021.