Mayo Clinic Laboratory and pathology research roundup: August 31

By Chantell Canfield • August 31, 2021

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Diagnosis and classification of ileal pouch disorders: consensus guidelines from the international Ileal pouch consortium.

Restorative proctocolectomy with ileal pouch-anal anastomosis is an option for most patients with ulcerative colitis or familial adenomatous polyposis who require colectomy. Although the construction of an ileal pouch substantially improves patients' health-related quality of life, the surgery is, directly or indirectly, associated with various structural, inflammatory, and functional adverse sequelae. Furthermore, the surgical procedure does not completely abolish the risk for neoplasia. Patients with ileal pouches often present with extraintestinal, systemic inflammatory conditions. The International Ileal Pouch Consortium was established to create this consensus document on the diagnosis and classification of ileal pouch disorders using available evidence and the panellists' expertise. In a given individual, the condition of the pouch can change over time. Therefore, close monitoring of the activity and progression of the disease is essential to make accurate modifications in the diagnosis and classification in a timely manner. Via PubMed

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Published to PubMed This Week

• Subgroup and subtype-specific outcomes in adult medulloblastoma.
  Acta Neuropathologica
• Mortality in individuals treated with COVID-19 convalescent plasma varies with the geographic provenance of donors.
  Nature Communications
• Spectroscopic label-free microscopy of changes in live cell chromatin and biochemical composition in transplantable organoids.
  Science Advances
• Genome-wide microRNA expression profiling of molecular subgroups of peripheral T-cell lymphoma.
  Clinical Cancer Research
• Disease burden, risk factors, and recent trends of liver cancer: A global country-level analysis.
  Liver Cancer
• IgA nephropathy presenting as macroscopic hematuria in 2 pediatric patients after receiving the Pfizer COVID-19 vaccine.
  Kidney International
• Light chain crystalline podocytopathy.
  Kidney International
• Clinical reasoning: A 49-year-old woman with progressive numbness and gait instability.
  Neurology
• Clinician perspectives on the use of artificial intelligence in inflammatory bowel disease.
  Gastrointest Endoscopy
• Primary papillary epithelial tumour of the sella: expanding the spectrum of TTF-1-positive sellar lesions.
  Neuropathol and Applied Neurobiology

Chantell Canfield

Chantell Canfield is a web content coordinator for Mayo Clinic Laboratories. She began working for Mayo Clinic in 2021.