Mayo Clinic Laboratory and pathology research roundup: February 22

By Chantell Canfield • February 22, 2022

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Deep residual inception encoder-decoder network for amyloid PET harmonization.

Multiple positron emission tomography (PET) tracers are available for amyloid imaging, posing a significant challenge to consensus interpretation and quantitative analysis. We accordingly developed and validated a deep learning model as a harmonization strategy.

Read more.

Published to PubMed This Week

• Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities.
  Nature Communications
• Associations of history of vaccination and hospitalization due to infection with risk of monoclonal B-cell lymphocytosis.
  Leukemia
• Genetic polymorphisms and correlation with treatment induced cardiotoxicity and prognosis in breast cancer patients.
  Clinical Cancer Research
• Mass-Fix better predicts for PFS and OS than standard methods among multiple myeloma patients participating on the STAMINA trial (BMT CTN 0702 /07LT).
  Blood Cancer Journal
• Anti-neuronal nuclear antibody 3 autoimmunity targets dachshund homolog 1.
  Annals of Neurology
• Characterisation of TRIM46 autoantibody-associated paraneoplastic neurological syndrome.
  Journal of Neurology, Neurosurgery and Psychiatry
• Midostaurin therapy for advanced systemic mastocytosis: Mayo Clinic experience in 33 consecutive cases.
  American Journal Hemotology
• Prognostic significance of acquired 1q22 gain in multiple myeloma.
  American Journal Hemotology
• SF3B1-mutant myelodysplastic syndrome/myeloproliferative neoplasms: a unique molecular and prognostic entity.
  Haematologica
• Erythrocytosis associated with EPAS1(HIF2A), EGLN1(PHD2), VHL, EPOR or BPGM mutations: The Mayo Clinic experience.
  Haematologica

Chantell Canfield

Chantell Canfield is a web content coordinator for Mayo Clinic Laboratories. She began working for Mayo Clinic in 2021.