Small Fiber Neuropathy: Diagnosis and Treatment


The complex field of neuropathy can be challenging for any neurologist, but add on to that the recent discoveries related to small-fiber neuropathy and the growing incidence of autoimmune etiology and it can quickly become overwhelming. This “Specialty Testing” webinar will discuss the considerations physicians must weigh when evaluating suspected neuropathy patients, with special emphasis on small-fiber neuropathy and the most appropriate laboratory testing related to that phenotype. Understanding the clinical features and being able to identify the potential comorbidities associated with this rare but increasing disease can prevent delays in diagnosis. Furthermore, understanding the diagnostic potential and limitations of associated laboratory testing will assist clinicians with test interpretation.


Video length: 50 minute


Christopher Klein, M.D.

Christopher Klein, M.D.

Professor of Neurology
Mayo Clinic College of Medicine and Science
Department of Neurology
Mayo Clinic, Rochester, Minnesota

Learning objectives

Upon completion of this activity, participants should be able to:

  • Discuss recent discoveries related to SFN incidence, prevalence, comorbid conditions, longitudinal impairments and disabilities.
  • Identify appropriate laboratory testing to guide therapies.
  • Discuss role of autoantibody testing and highlight phenotype-specific approach.

Intended audience

This webinar is designed for any provider who sees patients with neurologic diseases (e.g., neurologists, psychiatrists, and primary care physicians, including internists and family care practitioners) as well as pathologists, laboratory directors, and laboratory send-out coordinators.


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This post was developed by our Education and Technical Publications Team.