Inflammatory Bowel Disease

Answers from the Lab

Mayo Clinic Laboratories’ IBDP2 serology panel detects for the presence of antibodies against Saccharomyces cerevisiae IgA and IgG, and anti-neutrophil cytoplasmic antibodies (pANCA) to confirm disease presence in patients for whom diagnosis is unclear. In this test specific episode of the  "Answers From the Lab" podcast, Melissa Snyder, Ph.D., explains how IBDP2, when used after first-line testing has failed, can distinguish between ulcerative colitis and Crohn’s disease.

“Ulcerative colitis and Crohn's disease are really clinical diagnoses where the physician takes into account the clinical picture, some imaging studies, and maybe pathology to make a diagnosis,” Dr. Snyder says. “And for most patients, this is enough. Inflammatory bowel disease serology testing can be useful in a small subset of patients to help when it's difficult to differentiate between ulcerative colitis and Crohn's disease.”

Inflammatory bowel disease serology testing at Mayo Clinic Laboratories incorporates measures that improve testing quality and ensure accuracy of test results, Dr. Snyder adds. “We want to make sure that when we provide a result to a patient, the patient can rely on that result, the physician can rely on that result.”

Listen to learn more about how IBDP2 can help distinguish between ulcerative colitis and Crohn’s disease for some patients with IBD.

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Useful information

  • Distinguishing between ulcerative colitis and Crohn disease in patients for whom the specific diagnosis is unclear based on endoscopic, pathologic, and imaging evaluations.
  • This test is not useful for determining the extent of disease in patients with inflammatory bowel disease or determining the response to disease-specific therapy including surgical resection of diseased intestine.

Specimen requirements


Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 1 mL

Performance information

  • Analytic time: Same day/1 day
  • Day(s) and time(s) performed: TBD

The latest

Barbara J. Toman

Barbara J. Toman is a Senior Communications Specialist at Mayo Clinic Laboratories. She is also the science writer for Mayo’s Neurosciences Update newsletter, which helps referring physicians to stay informed about Mayo’s treatment and research. Barbara has worked at Mayo Clinic since 2007. She enjoys international travel and cooking.