Mayo Clinic Laboratory and pathology research roundup: May 10

By Meghann Southwick • May 10, 2022

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Genome-wide association study reveals novel genetic loci: a new polygenic risk score for mitral valve prolapse.

Mitral valve prolapse (MVP) is a common valvular heart disease with a prevalence of >2% in the general adult population. Despite this high incidence, there is a limited understanding of the molecular mechanism of this disease, and no medical therapy is available for this disease. 

Read more.

Published to PubMed This Week

• Overall patient experience with a virtual hybrid hospital at home program.
  SAGE open medicine
• MRI enhancement patterns in 28 cases of clival chordomas.
  Journal of clinical neuroscience
• Letter to the editor regarding "fifth generation cellular networks and neurosurgery: A narrative review".
  World neurosurgery
• Lacrimal gland involvement in a patient with sarcoidosis.
  Cleveland Clinic journal of medicine
• Clonal compositions involving epigenetic regulator and splicing mutations in CHIP, CCUS, MDS, and CMML.
  Leukemia research
• Apparent coexistence of ETV6::RUNX1 and KMT2A::MLLT3 fusions due to a nonproductive KMT2A rearrangement in B-ALL.
  Leukemia and lymphoma
• A phase 1 and pharmacodynamic study of chronically-dosed, single-agent veliparib (ABT-888) in patients with BRCA1- or BRCA2-mutated cancer or platinum-refractory ovarian or triple-negative breast cancer.
  Cancer chemotherapy and pharmacology
• Clinical and laboratory profiles of SARS-CoV-2 Delta variant compared to pre-Delta variants.
  International journal of infectious diseases
• Genetic variants associated with circulating C-reactive protein levels and colorectal cancer survival: Sex-specific and lifestyle factors specific associations.
  International journal of cancer
• Accessory genomes drive independent spread of carbapenem-resistant klebsiella pneumoniae clonal groups 258 and 307 in Houston, TX.
  mBio

Meghann Southwick

Meghann Southwick is a marketing specialist for Mayo Clinic Laboratories. She has worked at Mayo Clinic since 2021.