Mayo Clinic Laboratory and pathology research roundup: May 24

By Meghann Southwick • May 24, 2022

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Monoclonal and oligoclonal anti-Platelet Factor 4 antibodies mediate VITT.

COVID-19 vaccines have been associated with a rare life-threatening thrombotic and thrombocytopenic adverse reaction, vaccine-induced immune thrombotic thrombocytopenia (VITT) characterized by high levels of platelet-activating anti-platelet factor 4 (PF4) antibodies.

Read more.

Published to PubMed This Week

• A novel substitution of proline (P32L) destabilises β2-microglobulin inducing hereditary systemic amyloidosis.
  Amyloid
• Effect of trapeziectomy on carpal stability.
  Hand
• Differential expansion and outcomes of ascending and descending degenerative thoracic aortic aneurysms.
  The Journal of thoracic and cardiovascular surgery
• Loss of dimethylated H3K27 (H3K27me2) expression is not a specific marker of malignant peripheral nerve sheath tumor (MPNST): An immunohistochemical study of 137 cases, with emphasis on MPNST and melanocytic tumors.
  Annals of diagnostic pathology
• Rescuing cancer immunity by plasma exchange in metastatic melanoma (ReCIPE-M1): protocol for a single-institution, open-label safety trial of plasma exchange to clear sPD-L1 for immunotherapy.
  BMJ open
• Magnetic resonance imaging (MRI) helps differentiate renal cell carcinoma with sarcomatoid differentiation from renal cell carcinoma without sarcomatoid differentiation
  Abdominal radiology
• MR elastography in primary sclerosing cholangitis: a pictorial review.
  Abdominal radiology
• Adenylate kinase 5 (AK5) autoimmune encephalitis: Clinical presentations and outcomes in three new patients.
  Journal of neuroimmunology
• Neuronal intermediate filament paraneoplastic autoimmunity complicating avelumab therapy of Merkel cell carcinoma.
  Journal of neuroimmunology
• MR elastography as a biomarker for prediction of early and late recurrence in HBV-related hepatocellular carcinoma patients before hepatectomy.
  European journal of radiology

Meghann Southwick

Meghann Southwick is a marketing specialist for Mayo Clinic Laboratories. She has worked at Mayo Clinic since 2021.