Mayo Clinic Laboratory and pathology research roundup: June 7
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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
Nuclear GSK-3β and oncogenic KRas lead to the retention of pancreatic ductal progenitor cells phenotypically similar to those seen in IPMN.
Glycogen synthase kinase-3β (GSK-3β) is a downstream target of oncogenic KRas and can accumulate in the nucleus in pancreatic ductal adenocarcinoma (PDA). To determine the interplay between oncogenic KRas and nuclear GSK-3β in PDA development, we generated Lox-STOP-Lox (LSL) nuclear-targeted GSK-3β animals and crossed them with LSL-KRasG12D mice under the control of the Pdx1-cre transgene-referred to as KNGC. Altogether, these data identify nGSK-3β and KRasG12D as an important signaling node promoting the retention of pancreatic ductal progenitor cells.
Published to PubMed This Week
- Performance of plasma phosphorylated tau 181 and 217 in the community.
Nature medicine - Spectrum of sublytic astrocytopathy in neuromyelitis optica.
Brain: a journal of neurology - Latent pulmonary vascular disease may alter the response to therapeutic atrial shunt device in heart failure.
Circulation - IL-13Rα2 status predicts GB-13 (IL13.E13K-PE4E) efficacy in high-grade glioma.
Pharmaceutics - Artificial intelligence enhances diagnostic flow cytometry workflow in the detection of minimal residual disease of chronic lymphocytic leukemia.
Cancers - Deep neural network for cardiac magnetic resonance image segmentation.
Journal of imaging - Smoldering giant cell arteritis in a coronary artery.
Rheumatology
