Mayo Clinic Laboratory and pathology research roundup: July 12

By Samantha Rossi • July 12, 2022

Share this:

The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

PFKFB3 works on the FAK-STAT3-SOX2 axis to regulate the stemness in MPM. 

Malignant pleural mesothelioma (MPM) is an aggressive neoplasm and often acquires chemoresistance by increasing stemness in tumour tissue, thereby generating cancer stem cells (CSCs). CSCs escape treatment by deploying metabolic pathways to trigger dormancy or proliferation, also gaining the ability to exit and re-enter the cell cycle to hide their cellular identity.

Read more.

Published to PubMed This Week

• Development of a PTHrP chemiluminescent immunoassay to assess humoral hypercalcemia of malignancy. 
  Clinical biochemistry
• 1.5 million platelet count limit at essential thrombocythemia diagnosis: correlations and relevance to vascular events. 
  Blood advances
• Identification of a cryptic t(8;20;21)(q22;p13;q22) resulting in RUNX1T1/RUNX1 fusion in a patient with newly diagnosed Acute Myeloid Leukemia. 
  Laboratory medicine
• Chronic phase CML with sole P190 (e1a2) BCR::ABL1: long-term outcome among ten consecutive cases. 
  Blood cancer journal
• High-sensitivity cardiac troponin and the 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR guidelines for the evaluation and diagnosis of acute chest pain. 
  Circulation
• Correspondence on "Standards for the classification of pathogenicity of somatic variants in cancer (oncogenicity): Joint recommendations of Clinical Genome Resource (ClinGen), Cancer Genomics Consortium (CGC), and Variant Interpretation for Cancer Consortium (VICC)" by Horak et al. 
  Genetics in medicine : official journal of the American College of Medical Genetics
• The biological variability of plasma ceramides in healthy subjects. 
  The journal of applied laboratory medicine
• Comparison of five common analyzers in the measurement of chemistry analytes in an authentic cohort of body fluid specimens. 
  American journal of clinical pathology
• Revisiting the definition of perioperative myocardial infarction after coronary artery bypass grafting. 
  European heart journal
• Machine learning techniques differentiate alcohol-associated hepatitis from acute cholangitis in patients with systemic inflammation and elevated liver enzymes. 
  Mayo Clinic proceedings
• Postirradiation angiosarcoma of the urinary bladder. 
  Mayo Clinic proceedings
• Anticoagulation after bioprosthetic aortic valve replacement: are we following the guidelines? 
  The Annals of thoracic surgery
• Characterization of unusual iAMP21 B-lymphoblastic leukemia (iAMP21-ALL) from the Mayo Clinic and Children's Oncology Group. 
  Genes, chromosomes & cancer
  
  

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.