Mayo Clinic Laboratory and pathology research roundup: August 16

By Samantha Rossi • August 16, 2022

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Identification of caveolae-associated protein 4 autoantibodies as a biomarker of immune-mediated rippling muscle disease in adults

Immune-mediated rippling muscle disease (iRMD) is a rare myopathy characterized by wavelike muscle contractions (rippling) and percussion- or stretch-induced muscle mounding. A serological biomarker of this disease is lacking. The findings indicate that cavin-4 IgG may be the first specific serological autoantibody biomarker identified in iRMD. Depletion of cavin-4 expression in muscle biopsies of patients with iRMD suggests the potential role of this autoantigen in disease pathogenesis.

Read more.

Published to PubMed This Week

• Factors associated with physical activity levels in patients with breast cancer
  The oncologist
• How do I warm HPC(A) products to maximize cell viability in the setting of cold agglutinin disease?
  Transfusion
• The relationship between wild-type transthyretin amyloid load and ligamentum flavum thickness in lumbar stenosis patients.
  World neurosurgery
• In special coagulation, think horses not zebras: a clotted sample from a patient with congenital disorder of glycosylation
  International journal of laboratory hematology
• Molecular testing for diagnosis of early Lyme disease
  American journal of clinical pathology
• Therapeutic drug monitoring and dosage adjustments of immunosuppressive drugs when combined with nirmatrelvir/ritonavir in patients with COVID-19
  Therapeutic drug monitoring
• Targeted versus shotgun metagenomic sequencing-based detection of microorganisms in sonicate fluid for periprosthetic joint infection diagnosis
  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
• Machine learning-based fragment selection improves the performance of qualitative PRM assays
  Journal of proteome research
• An update on laboratory-based diagnostic biomarkers for multiple sclerosis and beyond
  Clinical chemistry
• Abnormal CD13/HLA-DR expression pattern on myeloblasts predicts development of myeloid neoplasia in patients with clonal cytopenia of undetermined significance
  American journal of clinical pathology
• Deepening responses post upfront ASCT in newly diagnosed multiple myeloma in the era of novel agent induction therapy
  Transplantation and cellular therapy
• Immunohistochemical approach to genetic subtyping of anaplastic large cell lymphoma
  The American journal of surgical pathology
• Latiglutenase protects the mucosa and attenuates symptom severity in patients with celiac disease exposed to a gluten challenge
  Gastroenterology
• Into the future: a pilot study combining imaging with molecular profiling to predict resectability in ovarian cancer
  Gynecologic oncology
• Lung allograft standardized histological analysis (LASHA) template: a research consensus proposal
  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
• Risk, prevalence, and progression of glaucoma in eyes with age-related macular degeneration treated with intravitreal anti-VEGF injections
  American journal of ophthalmology
• Histologic evaluation in the diagnosis and management of celiac disease: practical challenges, current best practice recommendations and beyond
  Human pathology
• Anaplastic thyroid carcinoma, squamous cell carcinoma pattern
  Mayo Clinic proceedings
• Flow cytometry for B-cell subset analysis in immunodeficiencies
  Journal of immunological methods
• An enhanced ceramide-based approach for primary prevention of atherosclerotic events
  European heart journal open
• Cross talk between lysine methyltransferase Smyd2 and TGF-β-Smad3 signaling promotes renal fibrosis in autosomal dominant polycystic kidney disease
  American journal of physiology. Renal physiology
• Radiation-associated angiosarcoma of the breast with initial presentation as non-mass enhancement on MRI
  Radiology case reports
• Immunohistochemical expression of renin & GATA3 help distinguish juxtaglomerular cell tumors from renal glomus tumors
  Human pathology
• Identification of two genetic loci associated with leukopenia after chemotherapy in patients with breast cancer
  Clinical cancer research : an official journal of the American Association for Cancer Research
  

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.