Mayo Clinic Laboratory and pathology research roundup: September 20
The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
We sought to determine the predictive value of combining tumor molecular subtype and computerized tomography (CT) imaging for surgical outcomes after primary cytoreductive surgery in advanced stage high-grade serous ovarian cancer (HGSOC) patients. Women with higher CT-scores were more likely to have MES subtype tumors (p = 0.014). MES subtypes and a high CT-score were independently predictive of macroscopic disease and high surgical complexity. Preoperative CT imaging combined with tumor molecular subtyping can identify a subset of women unlikely to have resectable disease and likely to require high complexity surgery. Along with other clinical factors, these may refine predictive scores for resection and assist treatment planning. Investigating methods for pre-surgical molecular subtyping is an important next step.
Published to PubMed This Week
Tissue methylated DNA markers for sporadic pancreatic cancer are strongly associated with familial and genetically predisposed pancreatic cancer Pancreatology : official journal of the International Association of Pancreatology (IAP) Primary leptomeningeal lymphoma: clinicopathologic features of 2 rare phenotypes Journal of neuropathology and experimental neurology Coordination of intraoperative neurophysiologic monitoring technologist and surgery schedules Journal of medical systems Bone marrow amyloid: a comprehensive analysis of 1,469 samples, including amyloid type, clinical features, and morphologic distribution Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis Is unmeasurable residual disease (uMRD) the best surrogate endpoint for clinical trials, regulatory approvals and therapy decisions in chronic lymphocytic leukaemia (CLL)? Leukemia Histoplasma capsulatum complement fixation and immunodiffusion assay sensitivity in culture-confirmed cases of histoplasmosis: a 10-year retrospective review (2011 to 2020) Journal of clinical microbiology Causes of death in low-grade B-cell lymphomas in the rituximab era: a prospective cohort study Blood advances Characterization of transgenic NSG-SGM3 mouse model of precision radiation-induced chronic hyposalivation Radiation research Autologous umbilical cord blood-derived mononuclear cell therapy promotes cardiac proliferation and adaptation in a porcine model of right ventricle pressure overload Cell transplantation Sociodemographic factors and family use of remote infant viewing in neonatal intensive care Journal of perinatology : official journal of the California Perinatal Association Myogenesis defects in a patient-derived iPSC model of hereditary GNE myopathy NPJ Regenerative medicine A novel USP25::PDGFRA gene fusion in a 78 year old patient with a myeloid neoplasm Laboratory medicine Induced pluripotent stem cells for the treatment of liver diseases: novel concepts Cells, tissues, organs Monkeypox 2022: gearing up for another potential public health crisis Mayo Clinic proceedings Efficacy and toxicity of hydrogen peroxide producing electrochemical bandages in a porcine explant biofilm model Journal of applied microbiology Classification of BRCA2 variants of uncertain significance (VUS) using an ACMG/AMP model incorporating a homology-directed repair (HDR) functional assay Clinical cancer research : an official journal of the American Association for Cancer Research Short- and long-term biological variability of small dense LDL, HDL3, and triglyceride-rich lipoprotein cholesterol The journal of applied laboratory medicine Correspondence on "standards for the classification of pathogenicity of somatic variants in cancer (oncogenicity): joint recommendations of clinical genome resource (ClinGen), cancer genomics consortium (CGC), and variant interpretation for cancer consortium (VICC)" by Horak et al Genetics in medicine : official journal of the American College of Medical Genetics Anastomosing hemangioma Mayo Clinic proceedings Adverse karyotype subcategories in acute myeloid leukemia display significant differences in mutation composition and transplant-augmented survival Haematologica