Mayo Clinic Laboratory and pathology research roundup: October 18

By Samantha Rossi • October 18, 2022

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

How do I warm HPC(A) products to maximize cell viability in the setting of cold agglutinin disease?

High titers of cold agglutinins jeopardize the quality of an apheresis product meant for autologous or allogeneic transplant. Management of transplant patients with cold agglutinin disease (CAD) is often experience-based and under reported, yet decisions must be made quickly to optimize product management and patient outcomes. There remains a lack of data quantifying cell recovery and viability when using various warming methodologies.

Read more.

Published to PubMed This Week

• Anakinra-associated amyloidosis
  JAMA dermatology
• The retirement of CKMB
  European heart journal. Acute cardiovascular care
• Apparent coexistence of ETV6::RUNX1 and KMT2A::MLLT3 fusions due to a nonproductive KMT2A rearrangement in B-ALL
  Leukemia & lymphoma
• Color vision deficiency survey in anatomic pathology
  American journal of clinical pathology
• Prepubertal-type testicular tumors in postpubertal patients: epidermoid cyst and well-differentiated neuroendocrine tumor
  Mayo Clinic proceedings
• Abnormal CD13/HLA-DR expression pattern on myeloblasts predicts development of myeloid neoplasia in patients with clonal cytopenia of undetermined significance
  American journal of clinical pathology
• Development and evaluation of a core genome multilocus sequencing typing (cgMLST) scheme for serratia marcescens molecular surveillance and outbreak investigations
  Journal of clinical microbiology
• Author correction: performance of plasma phosphorylated tau 181 and 217 in the community
  Nature medicine
• Cancer and vascular comorbidity effects on dementia risk and neuropathology in the oldest-old
  Journal of Alzheimer's disease : JAD
• Mass spectrometric analysis of chondroitin sulfate-linked peptides
  Journal of proteins and proteomics
• Classification and diagnostic evaluation of nodal T- and NK-cell lymphomas
  Virchows Archiv : an international journal of pathology
• Pitfalls in diagnosing hypoglycemia due to exogenous insulin: validation and utility of an insulin analog assay
  Mayo Clinic proceedings
• IL-10 partly mediates the ability of MSC-derived extracellular vesicles to attenuate myocardial damage in experimental metabolic renovascular hypertension
  Frontiers in immunology
• Outcomes after treatment with cobimetinib in patients with Rosai-Dorfman disease based on KRAS and MEK alteration status
  JAMA oncology
• Balancing clinician workload through strategic patient panel designs
  Quality management in health care

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.