Mayo Clinic Laboratory and pathology research roundup: November 22

By Samantha Rossi • November 22, 2022

Share this:

The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Progression of chronic kidney disease following radical and partial nephrectomy

To compare renal functional outcomes, as determined by percent decline in estimated glomerular filtration rate (eGFR) and CKD stage progression following radical (RN) and partial nephrectomy (PN) stratified by preoperative CKD stage. We retrospectively evaluated adults treated with RN or PN between 1980 and 2018 for unilateral, sporadic, solid renal masses.Percent change in eGFR at 1 year was significantly worse for RN (n = 1724; 57%) compared with PN (n = 1322; 43%) for all preoperative CKD stages. RN was more likely to result in decline in eGFR and CKD stage progression compared to PN for patients with preoperative CKD stage IIIb or less.

Read more.

Published to PubMed This Week

• Glucocorticoids mediate transcriptome-wide alternative polyadenylation: potential mechanistic and clinical implications
  Clinical and translational science, 15
• Immune cells are increased in normal breast tissues of BRCA1/2 mutation carriers
  Breast cancer research and treatment
• Chylous ascites: reassessment of diagnostic criteria in patients with portal hypertension
  The American journal of gastroenterology
• Drug testing in support of the diagnosis of neonatal abstinence syndrome: the current situation
  Clinical biochemistry
• Comparison of intact protein and digested peptide techniques for high throughput proteotyping of ApoE
  Clinical proteomics, 19
• Pharmacologic treatment of delirium symptoms: A systematic review
  General hospital psychiatry, 79
• Reproductive risk factors associated with breast cancer in young women by molecular subtype
  Breast (Edinburgh, Scotland), 66
• Alternative lengthening of telomeres in primary hepatic neoplasms
  Human pathology
• Author Reply
  Urology, 169
• Mutations of FH and IDH may induce gliomagenesis by similar mechanisms
  Journal of neuropathology and experimental neurology
• Neuropathological findings in COVID-19: an autopsy cohort
  Journal of neuropathology and experimental neurology
• Sebaceous carcinoma of the eyelid: proposed nomenclature for multifocal and multicentric disease
  Ophthalmic plastic and reconstructive surgery
• Clinical use of a 16S ribosomal RNA gene-based sanger and/or next generation sequencing assay to test preoperative synovial fluid for periprosthetic joint infection diagnosis
  mBio
• Emerging innovations for lumbar spondylolisthesis management: a systematic review of active and prospective clinical trials
  Neurosurgical review, 45

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.