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Robin Patel, M.D., and team study the use of transcriptomic-based cellular deconvolution to identify infectious and non-infectious causes of failed joint replacement surgeries 

While periprosthetic joint infections are a rare complication of knee and hip replacement surgeries, their effects can be life-threatening for patients. To make matters worse, they can be difficult to distinguish from other causes of failed arthroplasties.

Now, new exploratory research by Robin Patel, M.D., a physician in Mayo Clinic’s Divisions of Clinical Microbiology and Public Health, Infectious Diseases and Occupational Medicine, and Director and Co-Director of Mayo Clinic’s Infectious Diseases Research Laboratory and Clinical Bacteriology Laboratory, respectively, and Cody R. Fisher, a Ph.D. student in the Mayo Clinic Graduate School of Biomedical Sciences, has found that the use of a “transcriptomic-based cellular deconvolution tool” called CIBERSORTx could potentially be used to detect infectious and non-infectious causes of failed joint replacement surgeries.

Read the full study in the Journal of Bone & Joint Surgery.

Click here to learn more about Mayo Clinic’s Infectious Diseases Laboratory and Dr. Patel’s research into improving the detection and diagnosis of prosthetic joint infections.

Cory Pedersen

Cory Pedersen is a senior marketing specialist for Mayo Clinic Laboratories.