Mayo Clinic Laboratory and pathology research roundup: December 27
By Samantha Rossi • December 27, 2022
The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.
Featured Abstract
The literature regarding the neuropathological findings in cases of SARS-CoV-2 infection, which causes coronavirus disease 2019 (COVID-19), is expanding. We identified 72 patients who died of COVID-19 (n = 48) or had recovered shortly before death (n = 24) and had autopsies performed at our institution (49 males, 23 females; median age at death 76.4 years, range: 0.0-95.0 years). Droplet digital polymerase chain reaction (ddPCR) for the detection of SARS-CoV-2 was performed (n = 58) in multiple brain regions.
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Published to PubMed This Week
Niche-mediated repair of airways is directed in an occupant-dependent manner Cell reports , 41 H3 G34 mutation assessment for diffuse gliomas in adults: when would testing be most diagnostically useful? Journal of neuropathology and experimental neurology , 82 Mutations of FH and IDH may induce gliomagenesis by similar mechanisms Journal of neuropathology and experimental neurology , 82 Small cell transformation in a patient with RET fusion-positive lung adenocarcinoma on pralsetinib JCO precision oncology , 69 Durable response seen in patients with refractory fistulizing perianal Crohn's disease using autologous mesenchymal stem cells on a dissolvable matrix: results from the phase I stem cell on matrix plug (STOMP) trial Diseases of the colon and rectum Artificial intelligence-augmented electrocardiography for left ventricular systolic dysfunction in patients undergoing high-sensitivity cardiac troponin T Acute cardiovascular care ACE2 and TMPRSS2 SARS-CoV-2 infectivity genes: deep mutational scanning and characterization of missense variants Human molecular genetics , 31 Distal radius fracture treatment outcomes in patients with ipsilateral hemiplegia or hemiparesis Hand Outcomes after treatment with cobimetinib in patients with rosai-dorfman disease based on KRAS and MEK alteration status JAMA oncology , 8 Financial hardship in breast cancer survivors: a prospective analysis of change in financial concerns over time Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer , 31 Liquid chromatography-tandem mass spectrometry for clinical diagnostics Nature reviews. Methods primers , 2 Expanding the platelet inventory to mitigate the impact of severe shortages American Society of Hematology. Education Program , 2022 Characterizing M-protein light chain glycosylation via mass spectrometry Clinical biochemistry , 109-110 Maintenance of remission and risk of relapse in myeloperoxidase positive antineutrophil cytoplasmic antibody-associated vasculitis with kidney involvement Clinical journal of the American Society of Nephrology : CJASN Culture media composition influences patient-derived organoid ability to predict therapeutic responses in gastrointestinal cancers JCI insight , 7 Glucocorticoids unmask silent non-coding genetic risk variants for common diseases Nucleic acids research , 50 Changes in all-cause and cause-specific mortality during the first year of the COVID-19 pandemic in Minnesota: population-based study BMC public health , 22 Research opportunities in the treatment of mitral valve prolapse: JACC expert panel Journal of the American College of Cardiology , 80 Dataset for the reporting of neoplasms of the heart, pericardium, and great vessels: recommendations from the International Collaboration on Cancer Reporting (ICCR) Virchows Archiv : an international journal of pathology An amelanotic choroidal lesion in a 68-year-old man JAMA ophthalmology Predictors of response to venetoclax plus hypomethylating agent therapy and survival in blast-phase myeloproliferative neoplasm Haematologica Acute symptomatic seizures secondary to myelin oligodendrocyte glycoprotein antibody-associated disease Epilepsia , 63 R2 advances in robotic-assisted spine surgery: comparative analysis of options, future directions, and bibliometric analysis of the literature Neurosurgical review , 46
