Chromosomal microarray better informs brain tumor diagnosis

Answers from the Lab

Molecular biomarkers are a critical component in the treatment of adult and pediatric brain tumors. In this test-specific episode of the "Answers From the Lab" podcast, Robert Jenkins, M.D., Ph.D., explains how Mayo Clinic Laboratories' chromosomal microarray provides more comprehensive and accurate tumor analysis compared with other test methods.

"The array test covers all the possibilities," Dr. Jenkins says. "It easily finds the various mutations that are essential for diagnosis and prognosis."

He notes that the chromosomal microarray is more accurate than fluorescence in situ hybridization (FISH), and requires less tumor content than methylation assay.

Each microarray is analyzed by an experienced Mayo Clinic pathologist. "We use our specialist knowledge about brain tumors and what we see in the microarray to generate a meaningful report that can guide a care plan for these complex brain tumors," Dr. Jenkins says.

Listen to learn more about Mayo Clinic Laboratories' chromosomal microarray assay.

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Useful information

  • Genomic characterization of tumor for copy number imbalances and loss of heterozygosity.
  • Assisting in the diagnosis and classification of malignant neoplasms.
  • Evaluating the prognosis for patients with malignant tumors.

Specimen requirements

Specimen Required (submit only 1 of the following specimens):

  • Specimen Type: Tissue
  • Container/Tube: Formalin-fixed, paraffin-embedded tumor tissue block.
  • Specimen Type: Slides
  • Container/Tube: 10 Consecutive, unstained, 5-micron-thick sections placed on positively charged slides and 1 hematoxylin and eosin-stained slide.

Ordering Guidance: This test is not performed on fresh tissue specimens. If testing is needed for fresh tissue specimens, order CMAT / Chromosomal Microarray, Tumor, Fresh or Frozen using Affymetrix Cytoscan HD.

Necessary Information: A reason for testing and pathology report are required for testing to be performed. Send information with specimen. Acceptable pathology reports include working drafts, preliminary pathology or surgical pathology reports.

Performance information

Analytic time: 10 to 21 days

Days performed: Monday through Friday

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Barbara J. Toman

Barbara J. Toman is a Senior Communications Specialist at Mayo Clinic Laboratories. She is also the science writer for Mayo’s Neurosciences Update newsletter, which helps referring physicians to stay informed about Mayo’s treatment and research. Barbara has worked at Mayo Clinic since 2007. She enjoys international travel and cooking.