Mayo Clinic Laboratory and pathology research roundup: April 11

By Samantha Rossi • April 11, 2023

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

A stress-induced cilium-to-PML-NB route drives senescence initiation.

Cellular senescence contributes to tissue homeostasis and age-related pathologies. However, how senescence is initiated in stressed cells remains vague. Here, we discover that exposure to irradiation, oxidative or inflammatory stressors induces transient biogenesis of primary cilia, which are then used by stressed cells to communicate with the promyelocytic leukemia nuclear bodies (PML-NBs) to initiate senescence responses in human cells. Mechanistically, a ciliary ARL13B-ARL3 GTPase cascade negatively regulates the association of transition fiber protein FBF1 and SUMO-conjugating enzyme UBC9.

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Published to PubMed This Week

• Acquired cystic disease-associated renal cell carcinoma.
  Mayo Clinic Proceedings
• Elementary overview of heavy metals.
  Clinical Chemistry
• Cross-sectional association between systemic metal concentrations and immune markers in patients with total joint arthroplasty.
  Frontiers in immunology
• Granulomatosis with polyangiitis presenting as obstructive uropathy and vasculitic myopathy.
  Rheumatology (Oxford, England)
• Cerebral and retinal infarction in bicuspid aortic valve.
  Journal of American Heart Association
• Incorporation of genetic studies in the kidney transplant evaluation clinic: The value of a multidisciplinary approach.
  Transplant
• Factors predicting survival following alloSCT in patients with therapy-related AML and MDS: a multicenter study.
  Bone Marrow Transplant
• Does metabolite matter? Defining target itraconazole and hydroxy-itraconazole serum concentrations for blastomycosis.
  Mycoses
• A five arm natural history study of nasal vestibulitis.
  Cancer Medicine
  

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.