Mayo Clinic Laboratory and pathology research roundup: April 25

By Samantha Rossi • April 25, 2023

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The research roundup provides an overview of the past week’s research from Mayo Clinic Laboratories consultants, including featured abstracts and a complete list of published studies and reviews.

Featured Abstract

Deficiency of the CD155-CD96 immune checkpoint controls IL-9 production in giant cell arteritis

Loss of function of inhibitory immune checkpoints, unleashing pathogenic immune responses, is a potential risk factor for autoimmune disease. Here, we report that patients with the autoimmune vasculitis giant cell arteritis (GCA) have a defective CD155-CD96 immune checkpoint. Macrophages from patients with GCA retain the checkpoint ligand CD155 in the endoplasmic reticulum (ER) and fail to bring it to the cell surface. CD155^low antigen-presenting cells induce expansion of CD4⁺CD96⁺ T cells, which become tissue invasive, accumulate in the blood vessel wall, and release the effector cytokine interleukin-9 (IL-9). In a humanized mouse model of GCA, recombinant human IL-9 causes vessel wall destruction, whereas anti-IL-9 antibodies efficiently suppress innate and adaptive immunity in the vasculitic lesions. 

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Published to PubMed This Week

• Imaging features of intraosseous hemangiomas: beyond the mobile spine and calvarium.
  Skeletal Radiology
• Genetic-guided oral P2Y₁₂ inhibitor selection and cumulative ischemic events after percutaneous coronary intervention.
  JACC. Cardiovascular interventions
• Global longitudinal strain is associated with mortality in patients with multiple myeloma.
  Journal of Clinical Medicine
• The liver and glycogen: In sickness and in health.
  International Journal of Molecular Science
• Pulmonary manifestations in VEXAS syndrome.
  Respiratory Medicine
• Clinical and prognostic impact of STAG2 mutations in myeloid neoplasms: the Mayo Clinic experience.
  Blood advances
• Brazilian consensus for diagnosis, management and treatment of hereditary transthyretin amyloidosis with peripheral neuropathy: Second edition.
  Arquivos de neuro-psiquiatria
• Clonally selected lines after CRISPR-Cas editing are not isogenic.
  The CRISPR Journal
• Exercise capacity, NT-proBNP, and exercise hemodynamics in adults post-fontan.
  Journal of American College of Cardiology
  

Samantha Rossi

Samantha Rossi is a Digital Marketing Manager at Mayo Clinic Laboratories. She supports marketing strategies for product management and specialty testing. Samantha has worked at Mayo Clinic since 2019.